Sandbox Reserved 1121: Difference between revisions
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{{Human C-reactive protein complexed with phosphocholine}} | {{Human C-reactive protein complexed with phosphocholine}} | ||
Human C-Reactive Protein (CRP) is an acute phase protein belonging to the highly conserved pentraxin protein family, like as its homologue, the Serum Amyloid P component (SAP) <ref name="Thompson">PMID: 10368284</ref>. Although it is a normal serum protein, its circulating concentration raises rapidly and extensively in a cytokine-mediated in response to an infection, an inflammation or a tissue injury. | Human C-Reactive Protein (CRP) is an acute phase protein belonging to the highly conserved pentraxin protein family, like as its homologue, the Serum Amyloid P component (SAP) <ref name="Thompson">PMID: 10368284</ref>. CRP was named this way because it was found that the protein could precipitate the "C" polysaccharide derived from ''Streptococcus pneumoniae'' cell wall <ref>PMID: 15337754</ref><ref name="kumar">PMID: 21541851</ref>. | ||
Although it is a normal serum protein (healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>), its circulating concentration raises rapidly and extensively in a cytokine-mediated in response to an infection, an inflammation or a tissue injury. Indeed, its rate cIn this way, serum CRP rate is empirically dose to detect many human disease <ref name="Thompson"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/>. CRP rate in serum is common use to detect the activity of a disease<ref name="Thompson" />. CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>. | |||
== Structure == | == Structure == | ||
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When CRP is bind to a multivalent ligand, C1q is able to recognize it. This mechanism is initiated the C3 convertase assembly, which is an enzyme involved in the innate response. Furthermore, multiple pentamers have to be close to each other in order to realize this assembly <ref name="Volanakis"/>. | When CRP is bind to a multivalent ligand, C1q is able to recognize it. This mechanism is initiated the C3 convertase assembly, which is an enzyme involved in the innate response. Furthermore, multiple pentamers have to be close to each other in order to realize this assembly <ref name="Volanakis"/>. | ||
== References == | == References == | ||
<references/> | <references/> | ||
