Sandbox Reserved 1124: Difference between revisions
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== Introduction == | == Introduction == | ||
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The determination of the crystallographic structure enabled the observation of the junction between the SH3 and SH2 domains. It allows the two adjacent faces of the SH3 domains to be closer. This association is strenghtened by Van der Waals interaction. Nevertheless, the proline-rich peptides can still bind to SH3 domains. And when the SH2 domain of Grb2 binds to a receptor, the ability of the SH3 domains to interact with Sos motifs does not change.<ref >PMID: 7716522</ref> | The determination of the crystallographic structure enabled the observation of the junction between the SH3 and SH2 domains. It allows the two adjacent faces of the SH3 domains to be closer. This association is strenghtened by Van der Waals interaction. Nevertheless, the proline-rich peptides can still bind to SH3 domains. And when the SH2 domain of Grb2 binds to a receptor, the ability of the SH3 domains to interact with Sos motifs does not change.<ref >PMID: 7716522</ref> | ||
== | == Functions and interactions with substrates == | ||
