Sandbox Reserved 1124: Difference between revisions
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autophosphorylation sites of growth factor receptors. This small protein is essential for multiple cellular functions such as embryonic development and cell proliferation. Moreover, Grb2 can be found in the cytosol, the nucleus and the plasmic membrane. | autophosphorylation sites of growth factor receptors. This small protein is essential for multiple cellular functions such as embryonic development and cell proliferation. Moreover, Grb2 can be found in the cytosol, the nucleus and the plasmic membrane. | ||
== | == Grb2 discovery == | ||
The relevance of Grb2 has been enlightened thanks to studies on ''Caenorhabditis elegans''. Sem-5, an homologue of Grb2, was found to be implied in the Let-60 pathway, an homologue of Ras.<ref name="polyprolin"/> | The relevance of Grb2 has been enlightened thanks to studies on ''Caenorhabditis elegans''. Sem-5, an homologue of Grb2, was found to be implied in the Let-60 pathway, an homologue of Ras.<ref name="polyprolin"/> | ||
