Sandbox Reserved 1125: Difference between revisions
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Overexpression of MMP-8, or inadequate control by TIMPs, can be associated with a lot of pathological conditions<ref>[http://www.enzim.hu/~lbarna/articles/19173605.pdf "Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S1′ Subsite of Matrix Metalloproteinase 8"]</ref>. | Overexpression of MMP-8, or inadequate control by TIMPs, can be associated with a lot of pathological conditions<ref>[http://www.enzim.hu/~lbarna/articles/19173605.pdf "Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S1′ Subsite of Matrix Metalloproteinase 8"]</ref>. | ||
*Psoriasis: In patient with psoriasis, highly elevated levels of nitric oxide (NO) are released at the surface of psoriatic plaques. The peroxynitrite-dependent activation of the collagenase MMP-8 may induce the formation of extended rete pegs.<ref>PMID:11786028</ref> | *Psoriasis: In patient with psoriasis, highly elevated levels of nitric oxide (NO) are released at the surface of psoriatic plaques. The peroxynitrite-dependent activation of the collagenase MMP-8 may induce the formation of extended rete pegs.<ref>PMID:11786028</ref> | ||
*Sclerosis | *Sclerosis: MMPs can directly disrupt components of the blood–brain barrier or act on receptors expressed by blood–brain barrier-ECs.<ref>DOI:10.1016/j.febslet.2011.04.066</ref> | ||
*Osteoarthritis | *Osteoarthritis | ||
*Rheumatoid arthritis | *Rheumatoid arthritis | ||
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=== Therapeutic potential === | === Therapeutic potential === | ||
*As potential markers for disease severity in viral respiratory infections<ref>PMID:22825827</ref> | *As potential markers for disease severity in viral respiratory infections<ref>PMID:22825827</ref> | ||
*As an actor in the body's response to wound healing and that the latter is the pathological consequence of the disease with detrimental effects<ref>PMID:26598687</ref> | *As an actor in the body's response to wound healing and that the latter is the pathological consequence of the disease with detrimental effects. Indeed, MMP-8 could remove damaged ECM components at the wounded site.<ref>PMID:26598687</ref> | ||
You can find very interesting pieces of information concerning MMPs related diseases and therapeutic potentials in a nature paper: [http://www.nature.com/nrd/journal/v13/n12/full/nrd4390.html "Is there new hope for therapeutic matrix metalloproteinase inhibition, Roosmarijn E. Vandenbroucke & Claude Libert"]. | You can find very interesting pieces of information concerning MMPs related diseases and therapeutic potentials in a nature paper: [http://www.nature.com/nrd/journal/v13/n12/full/nrd4390.html "Is there new hope for therapeutic matrix metalloproteinase inhibition, Roosmarijn E. Vandenbroucke & Claude Libert"]. | ||
