Sandbox Reserved 1122: Difference between revisions

Line 74:

Bcl-2 <scene name='71/719863/Scenelucas/1'>BH4</scene> domain mediates the interaction with MBII domain of Myc. This interaction enhance c-Myc half-life, resulting in an enhancing of its total activity. c-Myc is a well known oncoprotein (transcription factor) involved in many cancers as it regulates a lot of genes of the cell cycle.

=== Autoimmunity ===

Bcl-2 family members and notably Bcl-2 protein seem to play an important role in autoimmune diseases, along with the gene Bim. This gene encodes a protein Bcl-2L11 (Bcl-2 like) belonging to the Bcl-2 family. It controls the apoptosis of T and B lymphocytes as a proapoptotic. When mutated, the loss of apoptotic activity in the lymphocytes population can lead to an accumulation of aggressive lymphocytes developing autoantibodies resulting in autoimmune disorders in certain genetic background. <ref>[http://www.karger.com/Article/PDF/90773 Role of Bim and other Bcl-2 Family Members in Autoimmune and Degenerative Diseases]</ref>; In fact, a selection process of T-cells occur at several levels (for example when entering the thymus). Only 5% of these cells survive. When Bim is inactive, this proportion is much higer due to overexpression of Bcl-2 and lack of Bim proteins.<ref>[http://link.springer.com.scd-rproxy.u-strasbg.fr/article/10.1007%2Fs10495-008-0308-4 The Bcl-2 family in autoimmune and degenerative disorders]</ref>

Bcl-2 overexpression is also involved in the inhibition of the elimination of B-lymphocytes presenting B-Cell receptor targeting self-antigens.<ref>[http://link.springer.com.scd-rproxy.u-strasbg.fr/article/10.1007%2Fs10495-008-0308-4 The Bcl-2 family in autoimmune and degenerative disorders]</ref>

== Structural highlights ==

Sandbox Reserved 1122: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 74: / Line 74: @@
 Bcl-2 <scene name='71/719863/Scenelucas/1'>BH4</scene> domain mediates the interaction with MBII domain of Myc. This interaction enhance c-Myc half-life, resulting in an enhancing of its total activity. c-Myc is a well known oncoprotein (transcription factor) involved in many cancers as it regulates a lot of genes of the cell cycle.
+=== Autoimmunity ===
+Bcl-2 family members and notably Bcl-2 protein seem to play an important role in autoimmune diseases, along with the gene Bim. This gene  encodes a protein Bcl-2L11 (Bcl-2 like) belonging to the Bcl-2 family. It controls the apoptosis of T and B lymphocytes as a proapoptotic. When mutated, the loss of apoptotic activity in the lymphocytes population can lead to an accumulation of aggressive lymphocytes developing autoantibodies resulting in autoimmune disorders in certain genetic background. <ref>[http://www.karger.com/Article/PDF/90773 Role of Bim and other Bcl-2 Family Members in Autoimmune and Degenerative Diseases]</ref>; In fact, a selection process of T-cells occur at several levels (for example when entering the thymus). Only 5% of these cells survive. When Bim is inactive, this proportion is much higer due to overexpression of Bcl-2 and lack of Bim proteins.<ref>[http://link.springer.com.scd-rproxy.u-strasbg.fr/article/10.1007%2Fs10495-008-0308-4 The Bcl-2 family in autoimmune and degenerative disorders]</ref>
+Bcl-2 overexpression is also involved in the inhibition of the elimination of B-lymphocytes presenting B-Cell receptor targeting self-antigens.<ref>[http://link.springer.com.scd-rproxy.u-strasbg.fr/article/10.1007%2Fs10495-008-0308-4 The Bcl-2 family in autoimmune and degenerative disorders]</ref>
 == Structural highlights ==