Sandbox Reserved 1125: Difference between revisions
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== Function == | == Function == | ||
A major function of MMPs is thought to be the removal of ECM in tissue resorption. Because of their recognized | A major function of MMPs is thought to be the removal of ECM in tissue resorption. Because of their recognized roles in disease (see below) the MMPs have long been considered as pharmacological targets, but their multiplicity, associated with their variable expressions in different tissues and their apparently overlapping substrate specificities, have presented considerable challenges to those hoping to design suitable therapeutic inhibitors. | ||
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*Rheumatoid arthritis | *Rheumatoid arthritis | ||
*Osteoporosis | *Osteoporosis | ||
*Meningitis: The | *Meningitis: The behavior of MMPs towards the blood-brain barrier can induce the accumulation of blood-derived leukocytes in the central nervous system. | ||
*Alzheimer's disease | *Alzheimer's disease | ||
*Tumor | *Tumor growth and metastasis: MMPs play an important role in tumor invasion and progression and their activities are required for increased motility of the epithelial cells and for growth of metastasized tumor cells. Furthermore, MMPs have been shown to be an essential actor in angiogenesis and tumor cell intravasation, both of which are required for tumor cell growth and metastasis.<ref>PMID:10224222</ref> | ||
*Periodontitis: MMP-8 has been associated with the progression of periodontitis, a common inflammatory disease of the supporting structures of the teeth<ref>PMID:16928431</ref> | *Periodontitis: MMP-8 has been associated with the progression of periodontitis, a common inflammatory disease of the supporting structures of the teeth<ref>PMID:16928431</ref> | ||
What makes this MMP unique is its exclusive pattern of expression in inflammatory conditions: the density of the interstitial collagen network increases in inflamed tissue.<ref>PMID:9727011</ref> | What makes this MMP unique is its exclusive pattern of expression in inflammatory conditions: the density of the interstitial collagen network increases in inflamed tissue.<ref>PMID:9727011</ref> | ||
