Sandbox Reserved 1121: Difference between revisions

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Human C-Reactive Protein (CRP) is an acute phase protein belonging to the highly conserved pentraxin protein family, such as its homologue, the Serum Amyloid P component (SAP) <ref name="Thompson">PMID: 10368284</ref>. CRP was named this way because it was found that the protein could precipitate the "C" polysaccharide derived from ''Streptococcus pneumoniae'' cell wall <ref name="Black">PMID: 15337754</ref><ref name="kumar">PMID: 21541851</ref>.

Human C-Reactive Protein (CRP) is an acute phase protein belonging to the highly conserved pentraxin protein family, such as its homologue, the Serum Amyloid P component (SAP)<ref name="Thompson">PMID: 10368284</ref>. CRP was named this way because it was found that the protein could precipitate the "C" polysaccharide derived from ''Streptococcus pneumoniae'' cell wall<ref name="Black">PMID: 15337754</ref><ref name="kumar">PMID: 21541851</ref>.

Although CRP is a normal serum protein (healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>), its circulating concentration rises rapidly and extensively (as much as 1000-fold or more <ref name="Black"/>) in a cytokine-mediated in response to an infection, an inflammation or a tissue injury. In this way, serum CRP rate is empirically ~~dose~~ to detect many human ~~disease~~ <ref name="Thompson"/>. CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/> during inflammatory states: the acute phase response, in which the synthesis of a lot of plasma proteins ~~increased~~ <ref name="Black"/>.

Although CRP is a normal serum protein (healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>), its circulating concentration rises rapidly and extensively (as much as 1000-fold or more<ref name="Black"/>) in a cytokine-mediated way in response to an infection, an inflammation or a tissue injury. In this way, serum CRP rate is empirically dosed to detect many human diseases<ref name="Thompson"/>. CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/> during inflammatory states: the acute phase response, in which the synthesis of a lot of plasma proteins increases<ref name="Black"/>.

Sandbox Reserved 1121: Difference between revisions

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 {{Human C-reactive protein complexed with phosphocholine}}
-Human C-Reactive Protein (CRP) is an acute phase protein belonging to the highly conserved pentraxin protein family, such as its homologue, the Serum Amyloid P component (SAP) <ref name="Thompson">PMID: 10368284</ref>. CRP was named this way because it was found that the protein could precipitate the "C" polysaccharide derived from ''Streptococcus pneumoniae'' cell wall <ref name="Black">PMID: 15337754</ref><ref name="kumar">PMID: 21541851</ref>.
+Human C-Reactive Protein (CRP) is an acute phase protein belonging to the highly conserved pentraxin protein family, such as its homologue, the Serum Amyloid P component (SAP)<ref name="Thompson">PMID: 10368284</ref>. CRP was named this way because it was found that the protein could precipitate the "C" polysaccharide derived from ''Streptococcus pneumoniae'' cell wall<ref name="Black">PMID: 15337754</ref><ref name="kumar">PMID: 21541851</ref>.
-Although CRP is a normal serum protein (healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>), its circulating concentration rises rapidly and extensively (as much as 1000-fold or more <ref name="Black"/>) in a cytokine-mediated in response to an infection, an inflammation or a tissue injury. In this way, serum CRP rate is empirically dose to detect many human disease <ref name="Thompson"/>.  CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/> during inflammatory states: the acute phase response, in which the synthesis of a lot of plasma proteins increased <ref name="Black"/>.
+Although CRP is a normal serum protein (healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>), its circulating concentration rises rapidly and extensively (as much as 1000-fold or more<ref name="Black"/>) in a cytokine-mediated way in response to an infection, an inflammation or a tissue injury. In this way, serum CRP rate is empirically dosed to detect many human diseases<ref name="Thompson"/>.  CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/> during inflammatory states: the acute phase response, in which the synthesis of a lot of plasma proteins increases<ref name="Black"/>.