Interferon: Difference between revisions
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<StructureSection load='2hym' size=' | <StructureSection load='2hym' size='350' side='right' caption='Human interferon α/β receptor complex with interferon α-2 (PDB code [[2hym]])' scene='Interferons/Interferonaandreceptor/2'> | ||
'''Interferons''' were the first cytokines discovered and were identified by Isaacs and Lindenmann. These proteins were classified as interferons because they interfered with virus growth.<ref name="Isaacs" /> The initial experiments performed poorly characterized the interferons, and was based merely on bioactivity. Advances in scientific instrumentation and technique have allowed for greater understanding and visualization of not only the structure but also the mechanisms of the various types of inteferons.<ref name="Structure">PMID:2413490</ref> The interferons were originally classified as leukocyte ('''interferon-α'''), fibroblast ('''interferon-β'''), and immmune ('''interferon-γ'''), although today they are classified into types I (α, β, ε, κ, ω), II (γ), and III (λ).<ref name="Isaacs" /><ref name="Structure" /> | '''Interferons''' were the first cytokines discovered and were identified by Isaacs and Lindenmann. These proteins were classified as interferons because they interfered with virus growth.<ref name="Isaacs" /> The initial experiments performed poorly characterized the interferons, and was based merely on bioactivity. Advances in scientific instrumentation and technique have allowed for greater understanding and visualization of not only the structure but also the mechanisms of the various types of inteferons.<ref name="Structure">PMID:2413490</ref> The interferons were originally classified as leukocyte ('''interferon-α'''), fibroblast ('''interferon-β'''), and immmune ('''interferon-γ'''), although today they are classified into types I (α, β, ε, κ, ω), II (γ), and III (λ).<ref name="Isaacs" /><ref name="Structure" /> | ||
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