5cow: Difference between revisions

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'''Unreleased structure'''
==C. remanei PGL-1 Dimerization Domain==
<StructureSection load='5cow' size='340' side='right' caption='[[5cow]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cow]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5COW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5COW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cow OCA], [http://pdbe.org/5cow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cow RCSB], [http://www.ebi.ac.uk/pdbsum/5cow PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cellular RNA-protein (RNP) granules are ubiquitous and have fundamental roles in biology and RNA metabolism, but the molecular basis of their structure, assembly, and function is poorly understood. Using nematode "P-granules" as a paradigm, we focus on the PGL granule scaffold protein to gain molecular insights into RNP granule structure and assembly. We first identify a PGL dimerization domain (DD) and determine its crystal structure. PGL-1 DD has a novel 13 alpha-helix fold that creates a positively charged channel as a homodimer. We investigate its capacity to bind RNA and discover unexpectedly that PGL-1 DD is a guanosine-specific, single-stranded endonuclease. Discovery of the PGL homodimer, together with previous results, suggests a model in which the PGL DD dimer forms a fundamental building block for P-granule assembly. Discovery of the PGL RNase activity expands the role of RNP granule assembly proteins to include enzymatic activity in addition to their job as structural scaffolds.


The entry 5cow is ON HOLD  until Paper Publication
PGL germ granule assembly protein is a base-specific, single-stranded RNase.,Aoki ST, Kershner AM, Bingman CA, Wickens M, Kimble J Proc Natl Acad Sci U S A. 2016 Jan 19. pii: 201524400. PMID:26787882<ref>PMID:26787882</ref>


Authors: Aoki, S.T., Bingman, C.A., Wickens, M., Kimble, J.E.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description: C. remanei PGL-1 Dimerization Domain
<div class="pdbe-citations 5cow" style="background-color:#fffaf0;"></div>
[[Category: Unreleased Structures]]
== References ==
[[Category: Bingman, C.A]]
<references/>
__TOC__
</StructureSection>
[[Category: Aoki, S T]]
[[Category: Bingman, C A]]
[[Category: Kimble, J E]]
[[Category: Wickens, M]]
[[Category: Wickens, M]]
[[Category: Aoki, S.T]]
[[Category: Dimer]]
[[Category: Kimble, J.E]]
[[Category: Guanosine endonuclease]]
[[Category: Hydrolase]]
[[Category: P-granule]]
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