1d4n: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 1d4n |SIZE=350|CAPTION= <scene name='initialview01'>1d4n</scene>, resolution 2.00Å | |PDB= 1d4n |SIZE=350|CAPTION= <scene name='initialview01'>1d4n</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene> | |LIGAND= <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1a8e|1A8E]], [[1a8f|1A8F]], [[1d3k|1D3K]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d4n OCA], [http://www.ebi.ac.uk/pdbsum/1d4n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d4n RCSB]</span> | |||
}} | }} | ||
| Line 14: | Line 17: | ||
==Overview== | ==Overview== | ||
The X-ray crystallographic structures of two mutants (K206Q and H207E) of the N-lobe of human transferrin (hTF/2N) have been determined to high resolution (1.8 and 2.0 A, respectively). Both mutant proteins bind iron with greater affinity than native hTF/2N. The structures of the K206Q and H207E mutants show interactions (both H-bonding and electrostatic) that stabilize the interaction of Lys296 in the closed conformation, thereby stabilizing the iron bound forms. | The X-ray crystallographic structures of two mutants (K206Q and H207E) of the N-lobe of human transferrin (hTF/2N) have been determined to high resolution (1.8 and 2.0 A, respectively). Both mutant proteins bind iron with greater affinity than native hTF/2N. The structures of the K206Q and H207E mutants show interactions (both H-bonding and electrostatic) that stabilize the interaction of Lys296 in the closed conformation, thereby stabilizing the iron bound forms. | ||
==About this Structure== | ==About this Structure== | ||
| Line 34: | Line 34: | ||
[[Category: Woodworth, R C.]] | [[Category: Woodworth, R C.]] | ||
[[Category: Yang, H W.]] | [[Category: Yang, H W.]] | ||
[[Category: carbonate]] | [[Category: carbonate]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
| Line 43: | Line 41: | ||
[[Category: transferrin]] | [[Category: transferrin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:34:37 2008'' | ||
