2oz6

Crystal Structure of Virulence Factor Regulator from Pseudomonas aeruginosa in complex with cAMP

spinqualitylabelsall models 2oz6, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2oz6 is a 1 chain structure with sequence from "bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CMP Gene: vfr ("Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [VFR_PSEAE] Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Virulence Factor Regulator (Vfr) enhances Pseudomonas aeruginosa pathogenicity through its role as a global transcriptional regulator. The crystal structure of Vfr shows it is a winged-helix DNA-binding protein like its homologue cAMP Receptor Protein (CRP). In addition to an expected primary cAMP-binding site, a second ligand-binding site is nestled between the N-terminal domain and the C-terminal helix-turn-helix domain. Unlike CRP, Vfr is a symmetric dimer in the absence of DNA. Removal of seven disordered N-terminal residues of Vfr prevents growth of P. aeruginosa. Crystal Structure of Pseudomonas aeruginosa Virulence Factor Regulator.,Cordes TJ, Worzalla GA, Ginster AM, Forest KT J Bacteriol. 2011 Jun 10. PMID:21665969 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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