2c1w: Difference between revisions

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==Overview==

Small nucleolar RNAs (snoRNAs) play a key role in eukaryotic ribosome, biogenesis. In most cases, snoRNAs are encoded in introns and are released, through the splicing reaction. Some snoRNAs are, instead, produced by an, alternative pathway consisting of endonucleolytic processing of pre-mRNA., XendoU, the endoribonuclease responsible for this activity, is a, U-specific, metal-dependent enzyme that releases products with 2'-3', cyclic phosphate termini. XendoU is broadly conserved among eukaryotes, and it is a genetic marker of nidoviruses, including the severe acute, respiratory syndrome coronavirus, where it is essential for replication, and transcription. We have determined by crystallography the structure of, XendoU that, by refined search methodologies, appears to display a unique, ... ~~[[http://ispc.weizmann.ac.il/pmbin/getpm?16895992 (full description)]]~~

Small nucleolar RNAs (snoRNAs) play a key role in eukaryotic ribosome, biogenesis. In most cases, snoRNAs are encoded in introns and are released, through the splicing reaction. Some snoRNAs are, instead, produced by an, alternative pathway consisting of endonucleolytic processing of pre-mRNA., XendoU, the endoribonuclease responsible for this activity, is a, U-specific, metal-dependent enzyme that releases products with 2'-3', cyclic phosphate termini. XendoU is broadly conserved among eukaryotes, and it is a genetic marker of nidoviruses, including the severe acute, respiratory syndrome coronavirus, where it is essential for replication, and transcription. We have determined by crystallography the structure of, XendoU that, by refined search methodologies, appears to display a unique, fold. Based on sequence conservation, mutagenesis, and docking, simulations, we have identified the active site. The conserved structural, determinants of this site may provide a framework for attempting to design, antiviral drugs to interfere with the infectious nidovirus life cycle.

==About this Structure==

2C1W is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1W OCA]].

2C1W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1W OCA].

==Reference==

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[[Category: splicing independent processing]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on ~~Tue Oct 30 16~~:55:07 2007''

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 15:18:16 2007''

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@@ Line 5: / Line 5: @@
 ==Overview==
-Small nucleolar RNAs (snoRNAs) play a key role in eukaryotic ribosome, biogenesis. In most cases, snoRNAs are encoded in introns and are released, through the splicing reaction. Some snoRNAs are, instead, produced by an, alternative pathway consisting of endonucleolytic processing of pre-mRNA., XendoU, the endoribonuclease responsible for this activity, is a, U-specific, metal-dependent enzyme that releases products with 2'-3', cyclic phosphate termini. XendoU is broadly conserved among eukaryotes, and it is a genetic marker of nidoviruses, including the severe acute, respiratory syndrome coronavirus, where it is essential for replication, and transcription. We have determined by crystallography the structure of, XendoU that, by refined search methodologies, appears to display a unique, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16895992 (full description)]]
+Small nucleolar RNAs (snoRNAs) play a key role in eukaryotic ribosome, biogenesis. In most cases, snoRNAs are encoded in introns and are released, through the splicing reaction. Some snoRNAs are, instead, produced by an, alternative pathway consisting of endonucleolytic processing of pre-mRNA., XendoU, the endoribonuclease responsible for this activity, is a, U-specific, metal-dependent enzyme that releases products with 2'-3', cyclic phosphate termini. XendoU is broadly conserved among eukaryotes, and it is a genetic marker of nidoviruses, including the severe acute, respiratory syndrome coronavirus, where it is essential for replication, and transcription. We have determined by crystallography the structure of, XendoU that, by refined search methodologies, appears to display a unique, fold. Based on sequence conservation, mutagenesis, and docking, simulations, we have identified the active site. The conserved structural, determinants of this site may provide a framework for attempting to design, antiviral drugs to interfere with the infectious nidovirus life cycle.
 ==About this Structure==
-C1W is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1W OCA]].
+C1W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1W OCA].
 ==Reference==
@@ Line 26: / Line 26: @@
 [[Category: splicing independent processing]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:55:07 2007''
+''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 15:18:16 2007''