2c1d: Difference between revisions
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==Overview== | ==Overview== | ||
The sulfur-oxidizing enzyme system (Sox) of the chemotroph Paracoccus, pantotrophus is composed of several proteins, which together oxidize, hydrogen sulfide, sulfur, thiosulfate or sulfite and transfers the gained, electrons to the respiratory chain. The hetero-dimeric cytochrome c, complex SoxXA functions as heme enzyme and links covalently the sulfur, substrate to the thiol of the cysteine-138 residue of the SoxY protein of, the SoxYZ complex. Here, we report the crystal structure of the c-type, cytochrome complex SoxXA. The structure could be solved by molecular, replacement and refined to a resolution of 1.9A identifying the axial, heme-iron coordination involving an unusual Cys-251 thiolate of heme2., Distance measurements between the three heme groups provide deeper insight, into . | The sulfur-oxidizing enzyme system (Sox) of the chemotroph Paracoccus, pantotrophus is composed of several proteins, which together oxidize, hydrogen sulfide, sulfur, thiosulfate or sulfite and transfers the gained, electrons to the respiratory chain. The hetero-dimeric cytochrome c, complex SoxXA functions as heme enzyme and links covalently the sulfur, substrate to the thiol of the cysteine-138 residue of the SoxY protein of, the SoxYZ complex. Here, we report the crystal structure of the c-type, cytochrome complex SoxXA. The structure could be solved by molecular, replacement and refined to a resolution of 1.9A identifying the axial, heme-iron coordination involving an unusual Cys-251 thiolate of heme2., Distance measurements between the three heme groups provide deeper insight, into the electron transport inside SoxXA and merge in a better, understanding of the initial step of the aerobic sulfur oxidation process, in chemotrophic bacteria. | ||
==About this Structure== | ==About this Structure== | ||
2C1D is a | 2C1D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans] and [http://en.wikipedia.org/wiki/Paracoccus_pantotrophus Paracoccus pantotrophus] with ZN and HEC as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1D OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: sulfur oxidation]] | [[Category: sulfur oxidation]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 15:18:27 2007'' | ||
