2n9q: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Photoswitchable G-quadruplex== | |||
<StructureSection load='2n9q' size='340' side='right' caption='[[2n9q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n9q]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N9Q FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZW:4-{(E)-[4-(HYDROXYMETHYL)PHENYL]DIAZENYL}BENZYL+DIHYDROGEN+PHOSPHATE'>AZW</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9q OCA], [http://pdbe.org/2n9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n9q RCSB], [http://www.ebi.ac.uk/pdbsum/2n9q PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two-tetrad G-quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G-quadruplexes with K(+) ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para-para-substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G-quadruplex and an unstructured state after E-Z isomerization. | |||
Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.,Thevarpadam J, Bessi I, Binas O, Goncalves DP, Slavov C, Jonker HR, Richter C, Wachtveitl J, Schwalbe H, Heckel A Angew Chem Int Ed Engl. 2016 Feb;55(8):2738-42. doi: 10.1002/anie.201510269. Epub, 2016 Jan 25. PMID:26805928<ref>PMID:26805928</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 2n9q" style="background-color:#fffaf0;"></div> | ||
[[Category: Jonker, H | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bessi, I]] | |||
[[Category: Binas, O]] | |||
[[Category: Goncalves, D P.N]] | |||
[[Category: Heckel, A]] | |||
[[Category: Jonker, H R.A]] | |||
[[Category: Richter, C]] | |||
[[Category: Schwalbe, H]] | |||
[[Category: Slavov, C]] | [[Category: Slavov, C]] | ||
[[Category: Thevarpadam, J]] | [[Category: Thevarpadam, J]] | ||
[[Category: | [[Category: Wachtveitl, J]] | ||
[[Category: | [[Category: Dna]] | ||
[[Category: | [[Category: Photoswitch]] | ||
[[Category: Quadruplex]] | |||
Revision as of 02:38, 21 February 2016
Photoswitchable G-quadruplex
| ||||||||||||
