Sandbox Reserved 427: Difference between revisions

Line 30:

==Additional Features==

=====Synthesis=====

Synthesized in the liver. Will also include details about folding, posttranslational modification and chaperone proteins, if any.

=====Actin Binding Interactions=====

Vitamin D binding protein is also capable of interacting with actin at the domains shown in <scene name='48/483884/Dbp_actin_binding_site/1'>red</scene>.

Vitamin D binding protein is also capable of interacting with actin at the domains shown in <scene name='48/483884/Dbp_actin_binding_site/1'>red</scene>. This function occurs mainly in the bloodstream, as DBP binds to globular actin present in the plasma. It presents an important mechanism for clearing actin from necrotic or apoptotic tissue (Meier et all 2006)

=====~~Inhibitors~~=====

=====Other Interactions=====

"Macrophage modulation

Chemotaxis of C5 derived peptides

Transport of fatty acids and endotoxins

Inhibition of platelet induced aggregation

Osteoclast Activation" from Meier et al 2006 Figure 2

=====Role in Disease=====

Altered levels in hepatic failure, AHF, trauma, immune function.

Deficient mice show no phenotype. White and Cooke.

=====Other Notable Ligands=====

Sandbox Reserved 427: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 30: / Line 30: @@
 ==Additional Features==
 <Structure load='1j7e' size='300' frame='true' align='right' caption='1j7e, Vitamin D Binding Protein binds to many different different substrates including actin and various synthetic ligands.' scene='Insert optional scene name here' />
+=====Synthesis=====
+Synthesized in the liver. Will also include details about folding, posttranslational modification and chaperone proteins, if any.
 =====Actin Binding Interactions=====
-Vitamin D binding protein is also capable of interacting with actin at the domains shown in <scene name='48/483884/Dbp_actin_binding_site/1'>red</scene>.
+Vitamin D binding protein is also capable of interacting with actin at the domains shown in <scene name='48/483884/Dbp_actin_binding_site/1'>red</scene>. This function occurs mainly in the bloodstream, as DBP binds to globular actin present in the plasma. It presents an important mechanism for clearing actin from necrotic or apoptotic tissue (Meier et all 2006)
-=====Inhibitors=====
+=====Other Interactions=====
+"Macrophage modulation
+Chemotaxis of C5 derived peptides
+Transport of fatty acids and endotoxins
+Inhibition of platelet induced aggregation
+Osteoclast Activation" from Meier et al 2006 Figure 2
 =====Role in Disease=====
+Altered levels in hepatic failure, AHF, trauma, immune function.
+Deficient mice show no phenotype. White and Cooke.
 =====Other Notable Ligands=====
 <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br>