Telomerase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 19: | Line 19: | ||
<scene name='60/602706/Tert_catalytic_subunit/1'>TERT catalytic subunit</scene> contains 3 domains: reverse transcriptase domain (in green), and carboxy-terminal extension (CTE)(in blue), RNA binding domain (TRBD)(in red). Similar to its structural homologs, as noted above, the ring contains fingers, palm, and thumb sections <ref name='TER'/>. The reverse transcriptase domain represents the fingers and palm. It consists of a mixture of alpha helices and beta strands The TRBD domain is a helical structure that binds double and single stranded RNA, and is essential for RNP assembly and repeat addition processivity <ref name='RNP'>doi 10.1038/nsmb.1777</ref>. This fingers and palm is one of the most conserved portions across similar phylogeny. The thumb corresponds to the CTE, which is an elongated helical bundle that contains several surface-exposed long loops. Lastly, the TRBD is a helical structure that binds double and single stranded RNA. CTE and TRBD, the two terminal ends of the protein come together to form the ring-like structure <ref name='RNP'/>. | <scene name='60/602706/Tert_catalytic_subunit/1'>TERT catalytic subunit</scene> contains 3 domains: reverse transcriptase domain (in green), and carboxy-terminal extension (CTE)(in blue), RNA binding domain (TRBD)(in red). Similar to its structural homologs, as noted above, the ring contains fingers, palm, and thumb sections <ref name='TER'/>. The reverse transcriptase domain represents the fingers and palm. It consists of a mixture of alpha helices and beta strands The TRBD domain is a helical structure that binds double and single stranded RNA, and is essential for RNP assembly and repeat addition processivity <ref name='RNP'>doi 10.1038/nsmb.1777</ref>. This fingers and palm is one of the most conserved portions across similar phylogeny. The thumb corresponds to the CTE, which is an elongated helical bundle that contains several surface-exposed long loops. Lastly, the TRBD is a helical structure that binds double and single stranded RNA. CTE and TRBD, the two terminal ends of the protein come together to form the ring-like structure <ref name='RNP'/>. | ||
For details on the reverse transcriptase domain see [[Telomerase Reverse Transcriptase]]. | |||
== Active Site Chemistry == | == Active Site Chemistry == | ||
