5ev2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ev2 is ~~ON HOLD until Paper Publication~~

==Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal==

~~Authors~~: ~~Agrawal~~, A.A., ~~Jenkins~~, J.L., ~~Kielkopf~~, C.L.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ev2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV2 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EV2 FirstGlance].

~~Description:~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>

[[Category: Jenkins, J.L]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5ev1|5ev1]], [[5ev3|5ev3]], [[5ev4|5ev4]]</td></tr>

[[Category: Kielkopf, C.L]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ev2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev2 OCA], [http://pdbe.org/5ev2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev2 PDBsum]</td></tr>

[[Category: ~~Agrawal, A.A~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Agrawal, A A]]

[[Category: Jenkins, J L]]

[[Category: Kielkopf, C L]]

[[Category: Polypyrimidine tract]]

[[Category: Protein-rna complex]]

[[Category: Rna binding protein]]

[[Category: Rna binding protein-rna complex]]

[[Category: Rna recognition motif]]

[[Category: Rna splicing factor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ev2 is ON HOLD  until Paper Publication
+==Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal==
+<StructureSection load='5ev2' size='340' side='right' caption='[[5ev2]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
-Authors: Agrawal, A.A., Jenkins, J.L., Kielkopf, C.L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ev2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EV2 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>
-[[Category: Jenkins, J.L]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ev1|5ev1]], [[5ev3|5ev3]], [[5ev4|5ev4]]</td></tr>
-[[Category: Kielkopf, C.L]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ev2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev2 OCA], [http://pdbe.org/5ev2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev2 PDBsum]</span></td></tr>
-[[Category: Agrawal, A.A]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Agrawal, A A]]
+[[Category: Jenkins, J L]]
+[[Category: Kielkopf, C L]]
+[[Category: Polypyrimidine tract]]
+[[Category: Protein-rna complex]]
+[[Category: Rna binding protein]]
+[[Category: Rna binding protein-rna complex]]
+[[Category: Rna recognition motif]]
+[[Category: Rna splicing factor]]