5hh3

OxyA from Actinoplanes teichomyceticus

spinqualitylabelsall models 5hh3, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5hh3 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACT, GOL, HEM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Publication Abstract from PubMed Cyclization of glycopeptide antibiotic precursors occurs in either three or four steps catalyzed by Cytochrome P450 enzymes. Three of these enzymes have been structurally characterized to date with the second enzyme along the pathway, OxyA, escaping structural analysis. We are now able to present the structure of OxyAtei involved in teicoplanin biosynthesis - the same enzyme recently shown to be the first active OxyA homologue. In spite of the hydrophobic character of the teicoplanin precursor, the polar active site of OxyAtei and its affinity for certain azole inhibitors hint at its preference for substrates with polar decorations. This article is protected by copyright. All rights reserved. Structure of OxyA : completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade.,Haslinger K, Cryle MJ FEBS Lett. 2016 Jan 28. doi: 10.1002/1873-3468.12081. PMID:26820384 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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