Fibrinogen

spinqualitylabelsall models Crystal structure of glycosylated fibrinogen fragment D. Subunitα (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code 1n73) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. The fibrin forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. Structural insights Fibrinogen is composed of 2 copies each of 3 non-identical chains α, β, γ (Fba, Fbb, Fbg).

3D Structure of Fibrinogen

Updated on 02-March-2016

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• Fibrinogen α+β+γ chains
  • thrombin, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
    
  • 3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
    
  • 2xnx, 2xny - hFba+hFbb+hFbg + M1 protein
    
  • 2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
    
  • 1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
    
  • 1jy3, 1deq – cFba+cFbb+cFbg – cow
    
  • 1jy2 - cFba+cFbb+cFbg proteolytic fragment
    
  • 1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
    
  • 1m1j - heFba+heFbb+heFbg+peptide ligand – hen
    
  • 1ei3 - heFba+heFbb+heFbg
    
• Fibrinogen α chain
  • 1fzd – hFba EC domain
    
  • 1bbr – hFba+cε-thrombin
    
  • 2jor – cFba – NMR
    
  • 2baf – cFba
    
• Fibrinogen β chain
  • 1fzf, 1fzg – hFb fragment double-D +peptide ligand
    
  • 1fze, 1fza, 1fzb – hFb fragment D
    
• Fibrinogen γ chain
  • 2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
    
  • 2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
    
  • 2fib, 3fib - hFbg+peptide ligand
    
  • 1fib – hFbg+Ca
    
  • 1fic, 1fid – hFbg
    
  • 3fib – hFbg C terminal
    
  • 1dug – Fbg C-terminal/glutathione S-transferase – Schistosoma japonicum
    
  • 2hwl – hFbg peptide+prothrombin
    
  • 2y7l – hFbg + agglutinin-like protein
    

Proteopedia Page Contributors and Editors (what is this?)

David Canner, Mark Hoelzer, Michal Harel, Alexander Berchansky, Angel Herraez, Marius Mihasan