1gp7: Difference between revisions
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|PDB= 1gp7 |SIZE=350|CAPTION= <scene name='initialview01'>1gp7</scene>, resolution 2.6Å | |PDB= 1gp7 |SIZE=350|CAPTION= <scene name='initialview01'>1gp7</scene>, resolution 2.6Å | ||
|SITE= <scene name='pdbsite=CAA:Ca+Binding+Site+For+Chain+C'>CAA</scene> | |SITE= <scene name='pdbsite=CAA:Ca+Binding+Site+For+Chain+C'>CAA</scene> | ||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gp7 OCA], [http://www.ebi.ac.uk/pdbsum/1gp7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gp7 RCSB]</span> | |||
}} | }} | ||
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[[Category: Lin, Z.]] | [[Category: Lin, Z.]] | ||
[[Category: Zhang, H.]] | [[Category: Zhang, H.]] | ||
[[Category: calcium]] | [[Category: calcium]] | ||
[[Category: cardiotoxic activity]] | [[Category: cardiotoxic activity]] | ||
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[[Category: snake venom]] | [[Category: snake venom]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:48:36 2008'' | ||
Revision as of 17:48, 30 March 2008
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| 1gp7, resolution 2.6Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sites: | CAA | ||||||||||||
| Ligands: | CA | ||||||||||||
| Activity: | Phospholipase A(2), with EC number 3.1.1.4 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH
Overview
The crystal structure of an acidic phospholipase A(2) from Ophiophagus hannah (king cobra) has been determined by molecular replacement at 2.6-A resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with reasonable stereochemistry. The venom enzyme contains an unusual "pancreatic loop." The conformation of the loop is well defined and different from those in pancreas PLA(2), showing its structural variability. This analysis provides the first structure of a PLA(2)-type cardiotoxin. The sites related to the cardiotoxic and myotoxic activities are explored and the oligomer observed in the crystalline state is described.
About this Structure
1GP7 is a Single protein structure of sequence from Ophiophagus hannah. Full crystallographic information is available from OCA.
Reference
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:12217659
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