Sandbox Reserved 429: Difference between revisions
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[[Student Projects for UMass Chemistry 423 Spring 2016]] | [[Student Projects for UMass Chemistry 423 Spring 2016]] | ||
<StructureSection load='2jch' size='350' side='right' caption='caption for Molecular Playground (PDB entry [[2jch]])' scene=''> | |||
==Introduction== | ==Introduction== | ||
Saves cells from dying since the appearance of life | |||
Outline: | Outline: | ||
1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam. | 1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam. | ||
2) Ligands, in particular <scene name='48/483886/Lactivicin/2'>phenoxyacetyl lactivicin</scene>. Also, how PBP binds lactivicin. | 2) Ligands, in particular <scene name='48/483886/Lactivicin/2'>phenoxyacetyl lactivicin</scene>. Also, how PBP binds lactivicin. | ||
Sample green scene: Penicillin-binding protein has four ligands, one of which is <scene name='48/483886/Edo_ligand/1'>the electron-deficient olefin ligand or EDO</scene> | Sample green scene: Penicillin-binding protein has four ligands, one of which is <scene name='48/483886/Edo_ligand/1'>the electron-deficient olefin ligand or EDO</scene> | ||
==Overall Structure= | ==Overall Structure= | ||
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Ligand has oxyanion hole to further binding potential. How does this help? | Ligand has oxyanion hole to further binding potential. How does this help? | ||
==Binding Interactions== | ==Binding Interactions== | ||
==Additional Features== | ==Additional Features== | ||
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'''3)work as enzyme to catalyze synthesis of peptidoglycan''' | '''3)work as enzyme to catalyze synthesis of peptidoglycan''' | ||
==Quiz Question 1== | ==Quiz Question 1== | ||
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Shows the <scene name='48/483886/Conserved_residues_of_pbp/2'>conserved residues of Penicillin Binding Protein</scene> from most conserved to most variable.{{Template:ColorKey_ConSurf}} | Shows the <scene name='48/483886/Conserved_residues_of_pbp/2'>conserved residues of Penicillin Binding Protein</scene> from most conserved to most variable.{{Template:ColorKey_ConSurf}} | ||
==See Also== | ==See Also== | ||
Revision as of 21:57, 2 March 2016
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Penicillin binding protein/lactivicin (inhibitor) (2jch)[1]
by Tyler Carpenter, Samuel Pierce, Hyunjoon Choi, Anton El Khoury and Tiankai Zhang
Student Projects for UMass Chemistry 423 Spring 2016 <StructureSection load='2jch' size='350' side='right' caption='caption for Molecular Playground (PDB entry 2jch)' scene=>
Introduction
Saves cells from dying since the appearance of life Outline: 1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam. 2) Ligands, in particular phenoxyacetyl lactivicin. Also, how PBP binds lactivicin. Sample green scene: Penicillin-binding protein has four ligands, one of which is the electron-deficient olefin ligand or EDO
=Overall Structure
The secondary structures of PBP have certain affects on ligands TextToBeDisplayed Ligand has oxyanion hole to further binding potential. How does this help?
Binding Interactions
Additional Features
1)role in antibiotics and resistance the role of PBPsmetabolic pathways and enzymes are unique to bacteria in its synthesis is a very good target for drugs of selective toxicity
2)different PBPs and how they are classified into diverse categories found as both membrane-bound and cytoplasmic proteins
3)work as enzyme to catalyze synthesis of peptidoglycan
Quiz Question 1
Question related to PBP evolution and developing resistance to ß-lactams, likely related to active site mutations.
Shows the conserved residues of Penicillin Binding Protein from most conserved to most variable.
See Also
Credits
Introduction - Anton El Khoury
Overall Structure - Tyler Carpenter
Drug Binding Site - name of team member
Additional Features - Tiankai Zhang
Quiz Question 1 - Samuel Pierce
References
- ↑ Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ. Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. PMID:17676039 doi:10.1038/nchembio.2007.21
