4yb4: Difference between revisions
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==Crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium ion (II) and NADH== | |||
<StructureSection load='4yb4' size='340' side='right' caption='[[4yb4]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yb4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YB4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48Y:(1R,2S)-1-HYDROXYBUTANE-1,2,4-TRICARBOXYLIC+ACID'>48Y</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoisocitrate_dehydrogenase Homoisocitrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.87 1.1.1.87] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yb4 OCA], [http://pdbe.org/4yb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yb4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yb4 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HICDH_THET2 HICDH_THET2]] Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate. In addition, has high activity with citrate, but is inactive with 3-isopropylmalate.<ref>PMID:12427751</ref> <ref>PMID:20735360</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homoisocitrate dehydrogenase]] | |||
[[Category: Kuzuyama, T]] | |||
[[Category: Nishiyama, M]] | |||
[[Category: Takahashi, K]] | |||
[[Category: Tomita, T]] | [[Category: Tomita, T]] | ||
[[Category: | [[Category: Homoisocitrate dehydrogenase thermus thermophilus]] | ||
[[Category: | [[Category: Oxidoreductase]] | ||
Revision as of 03:47, 10 March 2016
Crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium ion (II) and NADH
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