4ykw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4ykw is ~~ON HOLD until Mar 04 2017~~

==Heat Shock Protein 90 Bound to CS312==

~~Authors~~: ~~Kang~~, Y.N., ~~Stuckey~~, J.A.

== Structural highlights ==

<table><tr><td colspan='2'>[[4ykw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YKW OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YKW FirstGlance].

~~Description~~: ~~Heat Shock Protein 90 Bound~~ to ~~CS312~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4ES:4-(2-CHLORO-4-NITROPHENYL)-6-METHYLPYRIMIDIN-2-AMINE'>4ES</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

[[Category: Stuckey, J.A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ykw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ykw OCA], [http://pdbe.org/4ykw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ykw RCSB], [http://www.ebi.ac.uk/pdbsum/4ykw PDBsum]</td></tr>

[[Category: ~~Kang, Y.N~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Kang, Y N]]

[[Category: Stuckey, J A]]

[[Category: Chaperone]]

[[Category: Chaperone-inhibitor complex]]

[[Category: Hsp 90]]

[[Category: Protein-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4ykw is ON HOLD  until Mar 04 2017
+==Heat Shock Protein 90 Bound to CS312==
+<StructureSection load='4ykw' size='340' side='right' caption='[[4ykw]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors: Kang, Y.N., Stuckey, J.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ykw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YKW FirstGlance]. <br>
-Description: Heat Shock Protein 90 Bound to CS312
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4ES:4-(2-CHLORO-4-NITROPHENYL)-6-METHYLPYRIMIDIN-2-AMINE'>4ES</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ykq|4ykq]], [[4ykr|4ykr]], [[4ykt|4ykt]], [[4yku|4yku]], [[4ykx|4ykx]], [[4yky|4yky]], [[4ykz|4ykz]]</td></tr>
-[[Category: Stuckey, J.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ykw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ykw OCA], [http://pdbe.org/4ykw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ykw RCSB], [http://www.ebi.ac.uk/pdbsum/4ykw PDBsum]</span></td></tr>
-[[Category: Kang, Y.N]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Kang, Y N]]
+[[Category: Stuckey, J A]]
+[[Category: Chaperone]]
+[[Category: Chaperone-inhibitor complex]]
+[[Category: Hsp 90]]
+[[Category: Protein-inhibitor complex]]