4z2n: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4z2n is ~~ON HOLD until Paper Publication~~

==Crystal structure of human FACT SPT16 middle domain==

~~Authors~~: ~~Tsunaka~~, Y., ~~Fujiwara~~, Y., ~~Oyama~~, T., ~~Hirose~~, S.~~, Morikawa, K~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[4z2n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2N FirstGlance]. <br>

~~Description:~~

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z2m|4z2m]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2n OCA], [http://pdbe.org/4z2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2n RCSB], [http://www.ebi.ac.uk/pdbsum/4z2n PDBsum]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SP16H_HUMAN SP16H_HUMAN]] Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).<ref>PMID:10912001</ref> <ref>PMID:11239457</ref> <ref>PMID:12934006</ref> <ref>PMID:16713563</ref> <ref>PMID:9489704</ref> <ref>PMID:9836642</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Fujiwara, Y]]

[[Category: Hirose, S]]

[[Category: Morikawa, K]]

[[Category: Oyama, T]]

[[Category: Tsunaka, Y]]

[[Category: ~~Morikawa, K]]~~

[[Category: Transcription]]

~~[[Category: Fujiwara, Y~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4z2n is ON HOLD  until Paper Publication
+==Crystal structure of human FACT SPT16 middle domain==
+<StructureSection load='4z2n' size='340' side='right' caption='[[4z2n]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
-Authors: Tsunaka, Y., Fujiwara, Y., Oyama, T., Hirose, S., Morikawa, K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4z2n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2N FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z2m|4z2m]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2n OCA], [http://pdbe.org/4z2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2n RCSB], [http://www.ebi.ac.uk/pdbsum/4z2n PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SP16H_HUMAN SP16H_HUMAN]] Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).<ref>PMID:10912001</ref> <ref>PMID:11239457</ref> <ref>PMID:12934006</ref> <ref>PMID:16713563</ref> <ref>PMID:9489704</ref> <ref>PMID:9836642</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fujiwara, Y]]
 [[Category: Hirose, S]]
+[[Category: Morikawa, K]]
 [[Category: Oyama, T]]
 [[Category: Tsunaka, Y]]
-[[Category: Morikawa, K]]
+[[Category: Transcription]]
-[[Category: Fujiwara, Y]]