5chl: Difference between revisions
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==Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex== | |||
<StructureSection load='5chl' size='340' side='right' caption='[[5chl]], [[Resolution|resolution]] 1.89Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5chl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CHL FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5chl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5chl OCA], [http://pdbe.org/5chl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5chl RCSB], [http://www.ebi.ac.uk/pdbsum/5chl PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/VPS72_DROME VPS72_DROME]] Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.<ref>PMID:15528408</ref> <ref>PMID:16299513</ref> [[http://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Liang, X]] | |||
[[Category: Pan, L]] | |||
[[Category: Shan, S]] | |||
[[Category: Wu, C]] | [[Category: Wu, C]] | ||
[[Category: Zhou, Z]] | [[Category: Zhou, Z]] | ||
[[Category: Chaperone]] | |||
[[Category: Histone]] | |||
[[Category: Remodeling complex]] | |||
Revision as of 03:53, 10 March 2016
Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex
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