5cxv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5cxv is ~~ON HOLD until Paper Publication~~

==Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium==

~~Authors~~: ~~Sun~~, B., ~~Feng~~, D., Li, X., ~~Kobilka~~, T.S., ~~Kobilka, B~~.K.

== Structural highlights ==

<table><tr><td colspan='2'>[[5cxv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CXV OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CXV FirstGlance].

~~Description:~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </td></tr>

[[Category: ~~Kobilka, T.S~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cxv OCA], [http://pdbe.org/5cxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cxv RCSB], [http://www.ebi.ac.uk/pdbsum/5cxv PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ACM1_HUMAN ACM1_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

__TOC__

</StructureSection>

[[Category: Lysozyme]]

[[Category: Feng, D]]

[[Category: Kobilka, B K]]

[[Category: Kobilka, T S]]

[[Category: Li, X]]

[[Category: Sun, B]]

[[Category: ~~Li, X~~]]

[[Category: Acetylcholine]]

[[Category: ~~Kobilka, B.K~~]]

[[Category: Allosteric regulation]]

[[Category: Carrier protein]]

[[Category: Cholinergic antagonist]]

[[Category: Gpcr]]

[[Category: Hydrolase]]

[[Category: Muscarinic m1]]

[[Category: Subtype selectivity]]

[[Category: Tiotropium receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5cxv is ON HOLD  until Paper Publication
+==Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium==
+<StructureSection load='5cxv' size='340' side='right' caption='[[5cxv]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Sun, B., Feng, D., Li, X., Kobilka, T.S., Kobilka, B.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5cxv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CXV FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-[[Category: Kobilka, T.S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cxv OCA], [http://pdbe.org/5cxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cxv RCSB], [http://www.ebi.ac.uk/pdbsum/5cxv PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ACM1_HUMAN ACM1_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
+__TOC__
+</StructureSection>
+[[Category: Lysozyme]]
 [[Category: Feng, D]]
+[[Category: Kobilka, B K]]
+[[Category: Kobilka, T S]]
+[[Category: Li, X]]
 [[Category: Sun, B]]
-[[Category: Li, X]]
+[[Category: Acetylcholine]]
-[[Category: Kobilka, B.K]]
+[[Category: Allosteric regulation]]
+[[Category: Carrier protein]]
+[[Category: Cholinergic antagonist]]
+[[Category: Gpcr]]
+[[Category: Hydrolase]]
+[[Category: Muscarinic m1]]
+[[Category: Subtype selectivity]]
+[[Category: Tiotropium receptor]]