5i0n: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5i0n is ~~ON HOLD~~

==PI4K IIalpha bound to calcium==

~~Authors~~: ~~Baumlova~~, A., ~~Boura~~, E.

== Structural highlights ==

<table><tr><td colspan='2'>[[5i0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I0N FirstGlance]. <br>

~~Description~~: ~~PI4K IIalpha bound~~ to ~~calcium~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0n OCA], [http://pdbe.org/5i0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0n RCSB], [http://www.ebi.ac.uk/pdbsum/5i0n PDBsum]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.

__TOC__

</StructureSection>

[[Category: Baumlova, A]]

[[Category: Boura, E]]

[[Category: ~~Baumlova, A~~]]

[[Category: Calcium]]

[[Category: Kinase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5i0n is ON HOLD
+==PI4K IIalpha bound to calcium==
+<StructureSection load='5i0n' size='340' side='right' caption='[[5i0n]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
-Authors: Baumlova, A., Boura, E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5i0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I0N FirstGlance]. <br>
-Description: PI4K IIalpha bound to calcium
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0n OCA], [http://pdbe.org/5i0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0n RCSB], [http://www.ebi.ac.uk/pdbsum/5i0n PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.
+__TOC__
+</StructureSection>
+[[Category: Baumlova, A]]
 [[Category: Boura, E]]
-[[Category: Baumlova, A]]
+[[Category: Calcium]]
+[[Category: Kinase]]
+[[Category: Transferase]]