5i3r: Difference between revisions

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'''Unreleased structure'''


The entry 5i3r is ON HOLD  until Mar 09 2017
==Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor==
 
<StructureSection load='5i3r' size='340' side='right' caption='[[5i3r]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Counago, R.M., Sorrell, F.J., Krojer, T., Elkins, J.M., Gileadi, O., Willson, T.M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Arruda, P., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5i3r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3R FirstGlance]. <br>
Description: Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDK:N-[6-(3-{[(CYCLOPROPYLMETHYL)SULFONYL]AMINO}PHENYL)-1H-INDAZOL-3-YL]CYCLOPROPANECARBOXAMIDE'>IDK</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i3o|5i3o]], [[4w9w|4w9w]], [[4w9x|4w9x]]</td></tr>
[[Category: Elkins, J.M]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
[[Category: Counago, R.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3r OCA], [http://pdbe.org/5i3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3r RCSB], [http://www.ebi.ac.uk/pdbsum/5i3r PDBsum]</span></td></tr>
[[Category: Krojer, T]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation.
__TOC__
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H]]
[[Category: Arruda, P]]
[[Category: Axtman, A]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
[[Category: Sorrell, F.J]]
[[Category: Counago, R M]]
[[Category: Arrowsmith, C.H]]
[[Category: Drewry, D]]
[[Category: Edwards, A.M]]
[[Category: Edwards, A M]]
[[Category: Willson, T.M]]
[[Category: Elkins, J M]]
[[Category: Gileadi, O]]
[[Category: Gileadi, O]]
[[Category: Arruda, P]]
[[Category: Krojer, T]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Structural genomic]]
[[Category: Savitsky, P]]
[[Category: Sorrell, F J]]
[[Category: Wells, C]]
[[Category: Willson, T M]]
[[Category: Zhang, C]]
[[Category: Zuercher, W]]
[[Category: Protein kinase domain]]
[[Category: Sgc]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 04:00, 10 March 2016

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

5i3r, resolution 2.40Å

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