Helicase: Difference between revisions
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<StructureSection load='1pjr' size='350' side='right' scene='' caption='DNA-dependent helicase PcrA (PDB code [[1pjr]])'> | <StructureSection load='1pjr' size='350' side='right' scene='' caption='DNA-dependent helicase PcrA (PDB code [[1pjr]])'> | ||
== Function == | |||
'''Helicase''' (Hel) is a motor protein which separates nucleic acid strands like DNA double helix or self-annealed RNA. They use ATP hydrolysis for energy. Hel falls into 5 superfamilies (SF1-SF5). Some Hel contain a Helicase and RNase D C terminal | '''Helicase''' (Hel) is a motor protein which separates nucleic acid strands like DNA double helix or self-annealed RNA. They use ATP hydrolysis for energy. Hel falls into 5 superfamilies (SF1-SF5). Some Hel contain a Helicase and RNase D C terminal | ||
Domain (HRDC). The α-thalassemia and mental retardation X-linked syndrome helicase (ATRX ), contains an ATRX-Dnmt3-Dnmt3L (ADD) domain in which many disease-related mutations are found. '''ATP-dependent helicase Rho''' is a protein involved in termination of transcription in prokaryotes. Rho binds to the transcription terminator site on single-stranded RNA. Rho forms a ring-shaped hexamer and advances along the mRNA until it reaches the RNA polymerase and causing it to dissociate from the DNA and end transcription. | Domain (HRDC). The α-thalassemia and mental retardation X-linked syndrome helicase (ATRX ), contains an ATRX-Dnmt3-Dnmt3L (ADD) domain in which many disease-related mutations are found. '''ATP-dependent helicase Rho''' is a protein involved in termination of transcription in prokaryotes. Rho binds to the transcription terminator site on single-stranded RNA. Rho forms a ring-shaped hexamer and advances along the mRNA until it reaches the RNA polymerase and causing it to dissociate from the DNA and end transcription. | ||
