Sandbox Reserved 1172: Difference between revisions
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== Disease Relevance == | == Disease Relevance == | ||
The LPA1 receptor, depending on its level of expression, has been linked to both protective functions in the presence of a disease as well as causing a particular illness. For example, in patients with heart diseases, LPA1 has been found to communicate with [[PI3K]], [https://en.wikipedia.org/wiki/Protein_kinase_B PKB], and [[ERK]] to induce a hypertrophic response in the heart in order to offset reduced heart contractions. In addition, due to LPA1's function of pain signaling, overexertion of this protein can cause both [ | The LPA1 receptor, depending on its level of expression, has been linked to both protective functions in the presence of a disease as well as causing a particular illness. For example, in patients with heart diseases, LPA1 has been found to communicate with [[PI3K]], [https://en.wikipedia.org/wiki/Protein_kinase_B PKB], and [[ERK]] to induce a hypertrophic response in the heart in order to offset reduced heart contractions. In addition, due to LPA1's function of pain signaling, overexertion of this protein can cause both [https://en.wikipedia.org/wiki/Allodynia allodynia] or [https://en.wikipedia.org/wiki/Hyperalgesia hyperalgesia], common symptoms of multiple sclerosis or a stroke. | ||
Because of the mitogen signaling activity of LPA1, abnormal expression or mutation of this receptor has been linked to tumor growth, survival, and migration in both liver and lung tumors. As recently discussed, the His40 on LPA1, when protonated, increased LPA binding affinity is increase by up to 1kcal/mol. Because of this, in an acidic environment that is typically produced by [https://en.wikipedia.org/wiki/Tumor_hypoxia hypoxic tumors] creating lactic acid, LPA1 activity is increased, allowing these tumors to continue to proliferate, migrate, and survive. | Because of the mitogen signaling activity of LPA1, abnormal expression or mutation of this receptor has been linked to tumor growth, survival, and migration in both liver and lung tumors. As recently discussed, the His40 on LPA1, when protonated, increased LPA binding affinity is increase by up to 1kcal/mol. Because of this, in an acidic environment that is typically produced by [https://en.wikipedia.org/wiki/Tumor_hypoxia hypoxic tumors] creating lactic acid, LPA1 activity is increased, allowing these tumors to continue to proliferate, migrate, and survive. | ||
