Sandbox Reserved 1174: Difference between revisions
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The LPA1 receptor consists of seven transmembrane alpha helices. There are more <scene name='72/721545/Polarity/1'>polar</scene> (red) resides on the intercellular and extracellular areas of the receptor, while most residues positioned inside the membrane are hydrophobic (blue). | The LPA1 receptor consists of seven transmembrane alpha helices. There are more <scene name='72/721545/Polarity/1'>polar</scene> (red) resides on the intercellular and extracellular areas of the receptor, while most residues positioned inside the membrane are hydrophobic (blue). | ||
The receptor lies in the membrane as shown in Figure 3, and as shown by the <scene name='72/721545/Membrane/1'>fatty acid</scene> bound to it in orange. | The receptor lies in the membrane as shown in Figure 3, and as shown by the <scene name='72/721545/Membrane/1'>fatty acid</scene> bound to it in orange. | ||
=== Structural Stabilization === | === Structural Stabilization === | ||
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The <scene name='72/721545/Ligand/1'>binding pocket</scene> for LPA inside the receptor consists of both polar and nonpolar residues. There are polar residues on the N terminus and along one side of the binding pocket. There is also a large hydrophobic pocket for the long acyl chain of LPA. | The <scene name='72/721545/Ligand/1'>binding pocket</scene> for LPA inside the receptor consists of both polar and nonpolar residues. There are polar residues on the N terminus and along one side of the binding pocket. There is also a large hydrophobic pocket for the long acyl chain of LPA. | ||
=== Comparison to S1P === | === Comparison to S1P === | ||
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=== Infertility === | === Infertility === | ||
=== Pain === | === Pain === | ||
== Endocannabinoids == | == Endocannabinoids == | ||
