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Lysophosphatidic Acid (LPA) consists of an unsaturated fatty acid chain, a glycerol backbone, and a free phosphate group (Figure 1). Lysophosphatidic acid is found in nearly all cells, tissues, and fluids of the body. LPA is present intracellularly as a precursor of phospholipid biosynthesis, and extracellularly as a signalling phospholipid. This page will focus on the signalling role of LPA.

Extracellularly, LPA is produced from lysophosphatidylcholine by the enzyme autotaxin. All of LPA’s activities are receptor mediated; the signalling lipid interacts with at least six G-protein coupled receptors LPA1-LPA6.

Extracellularly, LPA is produced from lysophosphatidylcholine by the enzyme autotaxin. Autotaxin was originally linked with metastasis, and this link was later discovered to be through the production of LPA, which signals cell proliferation.<ref name= "Boutin"> DOI: 10.1007/s00018-009-0056-9 </ref> All of LPA’s activities are receptor mediated; the signalling lipid interacts with at least six G-protein coupled receptors LPA1-LPA6.

Sandbox Reserved 1174: Difference between revisions

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Revision as of 12:01, 29 March 2016 view source Stephanie Kuhlman (talk \| contribs) 244 edits No edit summary ← Older edit		Revision as of 12:12, 29 March 2016 view source Stephanie Kuhlman (talk \| contribs) 244 edits No edit summary Newer edit →
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	Lysophosphatidic Acid (LPA) consists of an unsaturated fatty acid chain, a glycerol backbone, and a free phosphate group (Figure 1). Lysophosphatidic acid is found in nearly all cells, tissues, and fluids of the body. LPA is present intracellularly as a precursor of phospholipid biosynthesis, and extracellularly as a signalling phospholipid. This page will focus on the signalling role of LPA.		Lysophosphatidic Acid (LPA) consists of an unsaturated fatty acid chain, a glycerol backbone, and a free phosphate group (Figure 1). Lysophosphatidic acid is found in nearly all cells, tissues, and fluids of the body. LPA is present intracellularly as a precursor of phospholipid biosynthesis, and extracellularly as a signalling phospholipid. This page will focus on the signalling role of LPA.

	Extracellularly, LPA is produced from lysophosphatidylcholine by the enzyme autotaxin. All of LPA’s activities are receptor mediated; the signalling lipid interacts with at least six G-protein coupled receptors LPA<sub>1</sub>-LPA<sub>6</sub>.		Extracellularly, LPA is produced from lysophosphatidylcholine by the enzyme autotaxin. Autotaxin was originally linked with metastasis, and this link was later discovered to be through the production of LPA, which signals cell proliferation.<ref name= "Boutin"> DOI: 10.1007/s00018-009-0056-9 </ref> All of LPA’s activities are receptor mediated; the signalling lipid interacts with at least six G-protein coupled receptors LPA<sub>1</sub>-LPA<sub>6</sub>.