Sandbox Reserved 1171: Difference between revisions
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== Background == | == Background == | ||
Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates [[insulin]] secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential Type II | Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates [[insulin]] secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential [http://www.diabetes.org/living-with-diabetes/treatment-and-care/ Type II Diabetes treatments] (Kebede). Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration (Ma, 2016). GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43. | ||
== Structure == | == Structure == | ||
