Sandbox Reserved 1175: Difference between revisions
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== Relevance == | == Relevance == | ||
</StructureSection> | |||
==Clinical Testing== | ==Clinical Testing== | ||
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===Pain=== | ===Pain=== | ||
LPA, a signaling phospholipid, that attaches to three specific G-protein-coupled receptors. After an injury occurs LPA is released in the body. It then will activate G-protein-coupled receptors. Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle). The LPA signaling will activate GTPase RhoA. Once activated Rho translocates to the plasma membrane. Rho will activate Rho kinase (ROCK). Mice with the deletation of LPA<sub>1</sub> receptors were studied to see the role that LPA signaling played in pain. In a study done with mice, those without the LPA<sub>1</sub> receptor had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>. Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar" </ref>. | LPA, a signaling phospholipid, that attaches to three specific G-protein-coupled receptors. After an injury occurs LPA is released in the body. It then will activate G-protein-coupled receptors. Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle). The LPA signaling will activate GTPase RhoA. Once activated Rho translocates to the plasma membrane. Rho will activate Rho kinase (ROCK). Mice with the deletation of LPA<sub>1</sub> receptors were studied to see the role that LPA signaling played in pain. In a study done with mice, those without the LPA<sub>1</sub> receptor had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>. Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar" </ref>. | ||
===Fibrosis=== | |||
=== Fibrosis === | |||
To look at the effects of LPA on fibrosis, there was a study done with mice <ref> PMID:18066075 </ref>. It was seen that with targeted deletion of LPA receptors the mice would be cured from fibrosis. Mice who had fibrosis were given LPA1 regulated LPA-induced fibroblast. Over time the mice who had fibrosis began to have their lungs repaired. The amount of fluid in their lungs decreased. | To look at the effects of LPA on fibrosis, there was a study done with mice <ref> PMID:18066075 </ref>. It was seen that with targeted deletion of LPA receptors the mice would be cured from fibrosis. Mice who had fibrosis were given LPA1 regulated LPA-induced fibroblast. Over time the mice who had fibrosis began to have their lungs repaired. The amount of fluid in their lungs decreased. | ||
== References == | == References == | ||
<references/> | <references/> | ||
