Sandbox Reserved 1172: Difference between revisions
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== Introduction == | == Introduction == | ||
[[Image:General_Picture.png |200 px|left|thumb| General image of the | [[Image:General_Picture.png |200 px|left|thumb| General image of the LPA<sub>1</sub> receptor's seven alpha helices]] | ||
Lysophosphatidic Acid Receptor 1 (commonly referred to as | Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>) that bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent mitogen upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref>, ----------- LPA<sub>1</sub> is part of the larger EDG receptor family(link) which includes the more widely known sphingosine 1-phopshate receptors. | ||
== Structure == | == Structure == | ||
[[Image:ON7.png|200 px|left|thumb|LPA<sub>1</sub> receptor in tan, antagonist ON7 in green and red]] | [[Image:ON7.png|200 px|left|thumb|LPA<sub>1</sub> receptor in tan, antagonist ON7 in green and red]] | ||
