Sandbox Reserved 1174: Difference between revisions
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== Endocannabinoids == | == Endocannabinoids == | ||
The endocannabinoid system, located in the mammalian nervous system, regulates a variety of physiological processes including appetite, pain sensation, mood, and memory. Endocannabinoids, the natural ligands for cannabinoid receptors, are similar in structure to lysophosphatidic acid. Both the cannabinoid receptors and the LPA receptors have a preference for long unsaturated acyl chains. | The endocannabinoid system, located in the mammalian nervous system, regulates a variety of physiological processes including appetite, pain sensation, mood, and memory. Endocannabinoids, the natural ligands for cannabinoid receptors, are similar in structure to lysophosphatidic acid. Both the cannabinoid receptors and the LPA receptors have a preference for long unsaturated acyl chains.<ref name= "Chrencik"> | ||
Promiscuous ligand binding between these two pathways has potential functional and therapeutic implications. Certain endocannabinoids are able to the LPA<sub>1</sub> receptor and cause the same downstream signalling that the LPA signalling molecule does. | Promiscuous ligand binding between these two pathways has potential functional and therapeutic implications. Certain endocannabinoids are able to the LPA<sub>1</sub> receptor and cause the same downstream signalling that the LPA signalling molecule does. | ||
