Sandbox Reserved 1161: Difference between revisions
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=== Extracellular Domain === | === Extracellular Domain === | ||
This is the <scene name='72/721532/Ecl_trail_1/7'>Extracellular Loops</scene> shows the extracellular loops (ECL) 1, 2, and 3 highlighted in purple. Additionally in the ECL domain, a <scene name='72/721532/Ecl_trail_1/6'>Disulfide Bond</scene> is attached to Helix 3 and the Amino Acid chain between Helix 5 and the N terminus. | This is the <scene name='72/721532/Ecl_trail_1/7'>Extracellular Loops</scene> shows the extracellular loops (ECL) 1, 2, and 3 highlighted in purple. Additionally in the ECL domain, a <scene name='72/721532/Ecl_trail_1/6'>Disulfide Bond</scene> is attached to Helix 3 and the Amino Acid chain between Helix 5 and the N terminus. The disulfide bond is highlighted in yellow. | ||
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[[Image: Organic with clipped surface.png|100 px|left|thumb|Figure Legend]] | [[Image: Organic with clipped surface.png|100 px|left|thumb|Figure Legend]] | ||
<scene name='72/721532/Mavoglurant_in_pocket/4'>Mavoglurant | In the 7 transmembrane (7TM) domain, <scene name='72/721532/Mavoglurant_in_pocket/4'>Mavoglurant.</scene> is in the 7TM domain pocket. Also, the lysozyme is attached to the intercellular region of the 7TM Domain. | ||
== Function and Pathway == | == Function and Pathway == | ||
Revision as of 15:47, 29 March 2016
Human metabotropic glutamate receptor 5 transmembrane domain
<StructureSection load='4oo9' size='350' frame='true' side='right' caption='Human metabotropic glutamate receptor 5 transmembrane domain' <'scene='(Ionic_lock)'> The Human metabotropic glutamate receptor 5 transmembrane domain is a
Structure
Extracellular Domain
This is the Extracellular Loops shows the extracellular loops (ECL) 1, 2, and 3 highlighted in purple. Additionally in the ECL domain, a Disulfide Bond is attached to Helix 3 and the Amino Acid chain between Helix 5 and the N terminus. The disulfide bond is highlighted in yellow.
Binding Pocket
In the 7 transmembrane (7TM) domain, Mavoglurant. is in the 7TM domain pocket. Also, the lysozyme is attached to the intercellular region of the 7TM Domain.
Function and Pathway
Disease
Parkinson's
Receiving and responding to extracellular messages is critical to the proper function of the nervous system. Glutamate is the major excitory neurotransmitter of the CNS, and metabotropic glutamate receptor 5 will play a major role in glutamate signaling. Metabotropic glutamate receptor 5 transmembrane domain is a homodimeric GPCR that resides in the cellular membrane [1]. This domain is a member of the Class C GPCR family and can further be categorized into the Group I subgroup. The transmembrane domain will signal through a Gq/11 pathway. mGlu5 will bind glutamate to the extracellular Venus flytrap domain and the signal will be transduced across the membrane to a heterotrimeric G protein, which will ultimately lead to calcium release and activation of PKC. This will elicit a excitory post-synaptic repose and modulate long term potentiation. Human metabotropic glutamate receptor 5 is found throughout the central nervous system. Areas containing high concentrations of this protein are often involved involved in emotions and higher cognition[2]. The localization of mGlu5 in the CNS and the presence of multiple domains makes mGlu5 a possible target for treating schizophrenia, Fragile X, depression, anxiety,and Alzheimer's disease[2].
