Sandbox reserved 1169: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Brent Waibel (talk | contribs) No edit summary |
Brent Waibel (talk | contribs) No edit summary |
||
| Line 9: | Line 9: | ||
== Structure == | == Structure == | ||
=== Overall Structure === | === Overall Structure === | ||
[[Image:Nuerotensin membrane.jpg |100 px|left|thumb| | [[Image:Nuerotensin membrane.jpg |100 px|left|thumb|Neurotensin Incorporation in Membrane ]] | ||
Like other G protein-coupled receptors, the neurotensin receptor is composed of 3 distinct regions. An extracellular binding site where neurotensin binds and causes a conformational change of the protein, a region containing <scene name='72/727765/Overall_structure/1'>7 transmembrane alpha helices</scene> that transduce the signal from the extracellular side of the cell membrane to the intracellular side, and an intracellular region that, when activated by a conformational change in the protein, activates a [https://en.wikipedia.org/wiki/G_protein G protein] associated with this receptor. There are currently no crystal structures of the inactive form of the neurotensin receptor available. Without a representation of the inactive form, the conformational changes caused by agonist binding are still not completely known. | Like other G protein-coupled receptors, the neurotensin receptor is composed of 3 distinct regions. An extracellular binding site where neurotensin binds and causes a conformational change of the protein, a region containing <scene name='72/727765/Overall_structure/1'>7 transmembrane alpha helices</scene> that transduce the signal from the extracellular side of the cell membrane to the intracellular side, and an intracellular region that, when activated by a conformational change in the protein, activates a [https://en.wikipedia.org/wiki/G_protein G protein] associated with this receptor. There are currently no crystal structures of the inactive form of the neurotensin receptor available. Without a representation of the inactive form, the conformational changes caused by agonist binding are still not completely known. | ||
=== Neurotensin Binding Site === | === Neurotensin Binding Site === | ||
