Sandbox Reserved 1172: Difference between revisions
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== Structure == | == Structure == | ||
[[Image:ABP.png|300 px|left|thumb|Electrostatic illustration of the amphipathic binding pocket of the LPA<sub>1</sub> receptor.]] | [[Image:ABP.png|300 px|left|thumb|Electrostatic illustration of the amphipathic binding pocket of the LPA<sub>1</sub> receptor.]] | ||
The LPA<sub>1</sub> receptor protein is composed of 364 amino acids with a mass of approximately 41 kDa | The LPA<sub>1</sub> receptor protein is composed of 364 amino acids with a mass of approximately 41 kDa. Just as other G-protein coupled receptors, LPA<sub>1</sub> contains seven alpha helices which make up the seven transmembrane spanning domains with three intracellular loops and three extracellular loops. The amino terminus of this protein is located on the extracellular side of the membrane, while the carboxyl terminus is located on the intracellular side of the membrane.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref>. Within these helices is an amphipathic binding pocket which stabilizes the binding of its ligand, LPA. | ||
=== Key Ligand Interactions === | === Key Ligand Interactions === | ||
[[Image:ON7.png|300 px|right|thumb|Overall structure of the LPA<sub>1</sub> receptor in tan interacting with its antagonist, ON7, shown in green and red sticks.]] | [[Image:ON7.png|300 px|right|thumb|Overall structure of the LPA<sub>1</sub> receptor in tan interacting with its antagonist, ON7, shown in green and red sticks.]] | ||
