Sandbox Reserved 1172: Difference between revisions

Line 15:

== Function ==

The LPA1 receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA1 receptor has been found to have physiological effects on every organ system, indicating its wide range of functions. Specifically, this receptor has been found to initiate downstream signaling cascades with three Gα proteins: Gi/o, Gq/11, and G12/13. that signal for cell proliferation, survival, and migration. <ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.

The LPA1 receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA1 receptor has been found to have physiological effects on every organ system, indicating its wide range of functions. Specifically, this receptor has been found to initiate downstream signaling cascades with three Gα proteins: Gi/o, Gq/11, and G12/13. These Gα proteins begin signaling cascades with molecules such as [https://en.wikipedia.org/wiki/Phospholipase_C phospholipase C] and [[MAPK]] that signal for cell proliferation, survival, and migration. <ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.

' </ref>. Despite this receptor being expressed throughout the body, LPA1 has been found to be expressed highly in neural tissue, aiding in Schwann cell migration and myelination, formation of synapses, and glial cell growth. Recent studies have also found that the LPA1 receptor is important in pain signal initiation via a [https://en.wikipedia.org/wiki/Rho-associated_protein_kinase ROCK] pathway.

' </ref>.

Despite this receptor being expressed throughout the body, LPA1 has been found to be expressed highly in neural tissue, aiding in Schwann cell migration and myelination, formation of synapses, and glial cell growth. Recent studies have also found that the LPA1 receptor is important in pain signal initiation via a [https://en.wikipedia.org/wiki/Rho-associated_protein_kinase ROCK] pathway.

== Disease Relevance ==

Sandbox Reserved 1172: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 15: / Line 15: @@
 == Function ==
-The LPA<sub>1</sub> receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA<sub>1</sub> receptor has been found to have physiological effects on every organ system, indicating its wide range of functions. Specifically, this receptor has been found to initiate downstream signaling cascades with three G<sub>α</sub> proteins: G<sub>i/o</sub>, G<sub>q/11</sub>, and G<sub>12/13</sub>. that signal for cell proliferation, survival, and migration. <ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.
+The LPA<sub>1</sub> receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA<sub>1</sub> receptor has been found to have physiological effects on every organ system, indicating its wide range of functions. Specifically, this receptor has been found to initiate downstream signaling cascades with three G<sub>α</sub> proteins: G<sub>i/o</sub>, G<sub>q/11</sub>, and G<sub>12/13</sub>. These G<sub>α</sub> proteins begin signaling cascades with molecules such as [https://en.wikipedia.org/wiki/Phospholipase_C phospholipase C] and [[MAPK]] that signal for cell proliferation, survival, and migration. <ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.
-' </ref>. Despite this receptor being expressed throughout the body, LPA<sub>1</sub> has been found to be expressed highly in neural tissue, aiding in Schwann cell migration and myelination, formation of synapses, and glial cell growth. Recent studies have also found that the LPA<sub>1</sub> receptor is important in pain signal initiation via a [https://en.wikipedia.org/wiki/Rho-associated_protein_kinase ROCK] pathway.
+' </ref>.
+ Despite this receptor being expressed throughout the body, LPA<sub>1</sub> has been found to be expressed highly in neural tissue, aiding in Schwann cell migration and myelination, formation of synapses, and glial cell growth. Recent studies have also found that the LPA<sub>1</sub> receptor is important in pain signal initiation via a [https://en.wikipedia.org/wiki/Rho-associated_protein_kinase ROCK] pathway.
 == Disease Relevance ==