Sandbox Reserved 1160: Difference between revisions
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The binding pocket represents an interesting source of regulatory control of receptor activity. The binding pocket is only accessible by a relatively narrow, 7 <scene name='72/721531/Protien_sur/2'>entrance</scene> | The binding pocket represents an interesting source of regulatory control of receptor activity. The binding pocket is only accessible by a relatively narrow, 7 <scene name='72/721531/Protien_sur/2'>entrance</scene> | ||
Important Amino Acids: | Important Amino Acids: | ||
*<scene name='72/721531/Protien_bindtop/ | *<scene name='72/721531/Protien_bindtop/4'>Asparagine</scene> 747forms a hydrogen bond network with main chain carbonyl of 652 and the carbamate portion of mavoglurant. | ||
*Bicyclic ring surrounded by <scene name='72/721531/Protien_hydrophobic/1'>hydrophobic binding pocket</scene>. | *Bicyclic ring surrounded by <scene name='72/721531/Protien_hydrophobic/1'>hydrophobic binding pocket</scene>. | ||
*2 Catalytic <scene name='72/721531/Protien_bindmiddle/ | *2 Catalytic <scene name='72/721531/Protien_bindmiddle/2'>serine</scene> resides H-bond to the hyrdoxyl oxygen of our ligand. | ||
*A <scene name='72/721531/Protien_bindbottom/1'>water molecular</scene> inside of the binding pocket helps stabilize the inactive state. | *A <scene name='72/721531/Protien_bindbottom/1'>water molecular</scene> inside of the binding pocket helps stabilize the inactive state. | ||
