Sandbox Reserved 1177: Difference between revisions

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===Na+ Binding Pocket===

W321, which is positioned at the bottom of the hydrophobic pocket(green link from allie), sets the top of the <scene name='72/721548/Na_bind_pocket/12'>Na+ Binding Pocket</scene>. The Na+ ion binding pocket acts as a negative allosteric site for G protein activity. When Na+ enters the Na+ ion binding pocket, it coordinates with Asp95, Gln131, and S135, and shuts down the activity of the protein. When the G protein is in its active state, the Na+ ion binding pocket is collapsed, preventing the ~~entrance~~ of Na+. In this case, the Na+ ion is coordinated by a salt bridge to Asp113. The side chain atoms of Asp113 form a hydrogen bond network with Thr156, Ser361, Ser362, and Gln365, which prevents the coordination of a Na+ ion.

W321, which is positioned at the bottom of the hydrophobic pocket(green link from allie), sets the top of the <scene name='72/721548/Na_bind_pocket/12'>Na+ Binding Pocket</scene>. The Na+ ion binding pocket acts as a negative allosteric site for G protein activity. When Na+ enters the Na+ ion binding pocket, it coordinates with Asp95, Gln131, and S135, and shuts down the activity of the protein. When the G protein is in its active state, the Na+ ion binding pocket is collapsed, preventing the regulation of protein activity through a Na+ ion. In this case, the Na+ ion is coordinated by a salt bridge to Asp113. The side chain atoms of Asp113 form a hydrogen bond network with Thr156, Ser361, Ser362, and Gln365, which prevents the coordination of a Na+ ion.

== Neurotensin (Ligand) ==

Sandbox Reserved 1177: Difference between revisions

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@@ Line 9: / Line 9: @@
 ===Na+ Binding Pocket===
-W321, which is positioned at the bottom of the hydrophobic pocket(green link from allie), sets the top of the <scene name='72/721548/Na_bind_pocket/12'>Na+ Binding Pocket</scene>. The Na+ ion binding pocket acts as a negative allosteric site for G protein activity. When Na+ enters the Na+ ion binding pocket, it coordinates with Asp95, Gln131, and S135, and shuts down the activity of the protein. When the G protein is in its active state, the Na+ ion binding pocket is collapsed, preventing the entrance of Na+. In this case, the Na+ ion is coordinated by a salt bridge to Asp113. The side chain atoms of Asp113 form a hydrogen bond network with Thr156, Ser361, Ser362, and Gln365, which prevents the coordination of a Na+ ion.
+W321, which is positioned at the bottom of the hydrophobic pocket(green link from allie), sets the top of the <scene name='72/721548/Na_bind_pocket/12'>Na+ Binding Pocket</scene>. The Na+ ion binding pocket acts as a negative allosteric site for G protein activity. When Na+ enters the Na+ ion binding pocket, it coordinates with Asp95, Gln131, and S135, and shuts down the activity of the protein. When the G protein is in its active state, the Na+ ion binding pocket is collapsed, preventing the regulation of protein activity through a Na+ ion. In this case, the Na+ ion is coordinated by a salt bridge to Asp113. The side chain atoms of Asp113 form a hydrogen bond network with Thr156, Ser361, Ser362, and Gln365, which prevents the coordination of a Na+ ion.
 == Neurotensin (Ligand) ==