1h3z: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3z OCA], [http://www.ebi.ac.uk/pdbsum/1h3z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h3z RCSB]</span> | |||
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[[Category: pwwp]] | [[Category: pwwp]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:57:14 2008'' | ||
Revision as of 17:57, 30 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE
Overview
The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.
About this Structure
1H3Z is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.
Reference
Structural variation in PWWP domains., Slater LM, Allen MD, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:12842472
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