Sandbox Reserved 1174: Difference between revisions

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===Pain===

Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle)~~. When an injury occurs, lysophosphatidic acid is released in the body. It then binds to LPA1 and activates the three G proteins coupled to the receptor~~. The ~~G alpha protein G12/13 activates~~ GTPase RhoA. Once activated Rho translocates to the plasma membrane ~~and activates~~ Rho kinase (ROCK).

LPA, a signaling phospholipid, that attaches to three specific G-protein-coupled receptors. After an injury occurs LPA is released in the body. It then will activate G-protein-coupled receptors. Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle). The LPA signaling will activate GTPase RhoA. Once activated Rho translocates to the plasma membrane. Rho will activate Rho kinase (ROCK). Mice with the deletation of LPA1 receptors were studied to see the role that LPA signaling played in pain. In a study done with mice, those without the LPA1 receptor had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>. Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar"/>.

~~In a study done~~ with ~~mice, the role that LPA signaling played in pain was looked into through~~ the deletation of LPA1 receptors. ~~Those~~ without the LPA1 receptor had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>.

=== Fibrosis ===

Sandbox Reserved 1174: Difference between revisions

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 ===Pain===
-Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle). When an injury occurs, lysophosphatidic acid is released in the body. It then binds to LPA<sub>1</sub> and activates the three G proteins coupled to the receptor.  The G alpha protein G<sub>12/13</sub> activates GTPase RhoA. Once activated Rho translocates to the plasma membrane and activates Rho kinase (ROCK).
+LPA, a signaling phospholipid, that attaches to three specific G-protein-coupled receptors.  After an injury occurs LPA is released in the body.  It then will activate G-protein-coupled receptors.  Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle).  The LPA signaling will activate GTPase RhoA.  Once activated Rho translocates to the plasma membrane.  Rho will activate Rho kinase (ROCK).  Mice with the deletation of LPA<sub>1</sub> receptors were studied to see the role that LPA signaling played in pain.  In a study done with mice, those without the LPA<sub>1</sub> receptor had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>.  Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar"/>.
-In a study done with mice, the role that LPA signaling played in pain was looked into through the deletation of LPA<sub>1</sub> receptors. Those without the LPA<sub>1</sub> receptor had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>.
 === Fibrosis ===