Sandbox Reserved 1172: Difference between revisions

Line 15:

== Function ==

The LPA1 receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA1 receptor has been found to have physiological effects on every organ system, indicating its wide range of functions. Specifically, this receptor has been found to initiate downstream signaling cascades with three Gα proteins: Gi/o, Gq/11, and G12/13. These Gα proteins begin signaling cascades with molecules such as [https://en.wikipedia.org/wiki/Phospholipase_C phospholipase C] and [[MAPK]] that signal for cell proliferation, survival, and migration. <ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref>.Despite this receptor being expressed throughout the body, LPA1 has been found to be expressed highly in neural tissue, aiding in several different neurodevelopmental processes including growth and folding of the [https://www.dartmouth.edu/~rswenson/NeuroSci/chapter_11.html cerebral cortex] and the growth, survival, and migration of neural [https://en.wikipedia.org/wiki/Progenitor_cell progenitor cells] through its different [https://en.wikipedia.org/wiki/G_protein ~~link~~ G-protein] regulated pathways.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref>. Finally, LPA1 receptors expressed in neural tissue aid in Schwann cell migration and myelination through a signaling pathway with the [https://en.wikipedia.org/wiki/RAC1 Rac1] G-protein.<ref name="number5">PMID: 24115248</ref>.

The LPA1 receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA1 receptor has been found to have physiological effects on every organ system, indicating its wide range of functions. Specifically, this receptor has been found to initiate downstream signaling cascades with three Gα proteins: Gi/o, Gq/11, and G12/13. These Gα proteins begin signaling cascades with molecules such as [https://en.wikipedia.org/wiki/Phospholipase_C phospholipase C] and [[MAPK]] that signal for cell proliferation, survival, and migration. <ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref>.Despite this receptor being expressed throughout the body, LPA1 has been found to be expressed highly in neural tissue, aiding in several different neurodevelopmental processes including growth and folding of the [https://www.dartmouth.edu/~rswenson/NeuroSci/chapter_11.html cerebral cortex] and the growth, survival, and migration of neural [https://en.wikipedia.org/wiki/Progenitor_cell progenitor cells] through its different [https://en.wikipedia.org/wiki/G_protein G-protein] regulated pathways.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref>. Finally, LPA1 receptors expressed in neural tissue aid in Schwann cell migration and myelination through a signaling pathway with the [https://en.wikipedia.org/wiki/RAC1 Rac1] G-protein.<ref name="number5">PMID: 24115248</ref>.

Sandbox Reserved 1172: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

Revision as of 19:02, 30 March 2016 view source Chandler Mitchell (talk \| contribs) 56 edits No edit summary ← Older edit		Revision as of 17:52, 31 March 2016 view source Clayton Taylor (talk \| contribs) 125 edits No edit summary Newer edit →
Line 15:		Line 15:

	== Function ==		== Function ==
	The LPA<sub>1</sub> receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA<sub>1</sub> receptor has been found to have physiological effects on every organ system, indicating its wide range of functions. Specifically, this receptor has been found to initiate downstream signaling cascades with three G<sub>α</sub> proteins: G<sub>i/o</sub>, G<sub>q/11</sub>, and G<sub>12/13</sub>. These G<sub>α</sub> proteins begin signaling cascades with molecules such as [https://en.wikipedia.org/wiki/Phospholipase_C phospholipase C] and [[MAPK]] that signal for cell proliferation, survival, and migration. <ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref>.Despite this receptor being expressed throughout the body, LPA<sub>1</sub> has been found to be expressed highly in neural tissue, aiding in several different neurodevelopmental processes including growth and folding of the [https://www.dartmouth.edu/~rswenson/NeuroSci/chapter_11.html cerebral cortex] and the growth, survival, and migration of neural [https://en.wikipedia.org/wiki/Progenitor_cell progenitor cells] through its different [https://en.wikipedia.org/wiki/G_protein ~~link~~ G-protein] regulated pathways.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref>. Finally, LPA1 receptors expressed in neural tissue aid in Schwann cell migration and myelination through a signaling pathway with the [https://en.wikipedia.org/wiki/RAC1 Rac1] G-protein.<ref name="number5">PMID: 24115248</ref>.		The LPA<sub>1</sub> receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA<sub>1</sub> receptor has been found to have physiological effects on every organ system, indicating its wide range of functions. Specifically, this receptor has been found to initiate downstream signaling cascades with three G<sub>α</sub> proteins: G<sub>i/o</sub>, G<sub>q/11</sub>, and G<sub>12/13</sub>. These G<sub>α</sub> proteins begin signaling cascades with molecules such as [https://en.wikipedia.org/wiki/Phospholipase_C phospholipase C] and [[MAPK]] that signal for cell proliferation, survival, and migration. <ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref>.Despite this receptor being expressed throughout the body, LPA<sub>1</sub> has been found to be expressed highly in neural tissue, aiding in several different neurodevelopmental processes including growth and folding of the [https://www.dartmouth.edu/~rswenson/NeuroSci/chapter_11.html cerebral cortex] and the growth, survival, and migration of neural [https://en.wikipedia.org/wiki/Progenitor_cell progenitor cells] through its different [https://en.wikipedia.org/wiki/G_protein G-protein] regulated pathways.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref>. Finally, LPA1 receptors expressed in neural tissue aid in Schwann cell migration and myelination through a signaling pathway with the [https://en.wikipedia.org/wiki/RAC1 Rac1] G-protein.<ref name="number5">PMID: 24115248</ref>.