Ire1: Difference between revisions

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== Function ==

'''Ire1''' is a serine/threonine protein kinase/endoribonuclease. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:~~w23880584~~</ref>. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation.

'''Ire1''' is a serine/threonine protein kinase/endoribonuclease. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:23880584</ref>. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation.

== Structural highlights ==

Yeast Ire1 structure shows a different binding site for ADP and for quercetin. Quercetin is a powerful activator of Ire1. Ire1 binds 2 molecules of quercetin at its dimer interface<ref>PMID:23880584</ref>.

==3D structures of Ire1==

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 <StructureSection load='3lj0' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain dimer complex with quercetin, ADP (stick model), Ca+2 and Sr+2 ions (PDB entry [[3lj0]])' scene=''>
+== Function ==
-'''Ire1''' is a serine/threonine protein kinase/endoribonuclease.  It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:w23880584</ref>.  The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis.  The kinase domain of Ire1 is required for activation of the endoribonuclase domain.  Ire1 senses unfolded proteins causing its auto-activation.
+'''Ire1''' is a serine/threonine protein kinase/endoribonuclease.  It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:23880584</ref>.  The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis.  The kinase domain of Ire1 is required for activation of the endoribonuclase domain.  Ire1 senses unfolded proteins causing its auto-activation.
+== Structural highlights ==
+Yeast Ire1 structure shows a different binding site for ADP and for quercetin.  Quercetin is a powerful activator of Ire1.  Ire1 binds 2 molecules of quercetin at its dimer interface<ref>PMID:23880584</ref>.
 ==3D structures of Ire1==