Sandbox Reserved 426: Difference between revisions
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The 1xcs (model at right) complex is a small, simple globular DNA-drug complex, and as such lacks any traditional protein structures such as secondary beta sheets or alpha helices. The complex consists of two complimentary strands of DNA. A simplified model of 1xcs is shown <scene name='48/483883/Title/4'>here,</scene> with the nitrogenous bases removed for clarity. The deoxyribose backbones can be followed from 5' to 3' following along each strand from blue to red. Note that the strands are antiparallel where they are (hydrogen) bonded. <scene name='48/483883/1xcs_with_side_chains/2'>1xcs with its hydrogen bonding regions displayed (black)</scene> visualizes this bonding in the middle region of the complex, again following each strand from blue to red from 5' to 3' ends. | The 1xcs (model at right) complex is a small, simple globular DNA-drug complex, and as such lacks any traditional protein structures such as secondary beta sheets or alpha helices. The complex consists of two complimentary strands of DNA. A simplified model of 1xcs is shown <scene name='48/483883/Title/4'>here,</scene> with the nitrogenous bases removed for clarity. The deoxyribose backbones can be followed from 5' to 3' following along each strand from blue to red. Note that the strands are antiparallel where they are (hydrogen) bonded. <scene name='48/483883/1xcs_with_side_chains/2'>1xcs with its hydrogen bonding regions displayed (black)</scene> visualizes this bonding in the middle region of the complex, again following each strand from blue to red from 5' to 3' ends. | ||
The 1xcs complex also binds to metal ions in more than one location, which have been shown to be important to the drug's binding ability. Different metal ions may be present, including Na(+) and Co(2+). | |||
==Binding Interactions== | ==Binding Interactions== | ||
<scene name='48/483883/1xcs_binding_site/2'>Click here to see the binding site | <scene name='48/483883/1xcs_binding_site/2'>Click here to see the binding site | ||
1xcs is a complex with DNA and it is a two chain structure. It has ligands A4L, BA and CO. There are strong cation interactions that help form a crystal structure. The complex crystallizes when there | 1xcs is a complex with DNA and it is a two chain structure. It has ligands A4L, BA and CO. There are strong cation interactions that help form a crystal structure. The complex crystallizes when there are either Co(2+), Ba(2+) or Na(+) ions. </scene> | ||
