Sandbox Reserved 428: Difference between revisions
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==Overall Structure== | ==Overall Structure== | ||
The protein has an active conformation of 1,25 (OH)_2D_3 that has a ligand binding pocket in its active folded state. The ligand interacts with with the activation helix by stabilizing the | The protein has an active conformation of 1,25 (OH)_2D_3 that has a ligand binding pocket in its active folded state. The ligand interacts with with the activation helix by stabilizing the agonist position. This is accomplished through Van der Waals interactions between the ligand and the activation helix. The activation ligand is a nuclear receptor (VDR). | ||
There is some empty space observed around the | There is some empty space observed around the aliphatic chain. | ||
Diagram of Protein Protein indicates alpha helices, while yellow indicates beta sheets: | Diagram of Protein Protein indicates alpha helices, while yellow indicates beta sheets: | ||
Outline: | Outline: | ||
