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| {{STRUCTURE_2ips| PDB=2ips | SIZE=400| SCENE= |right|CAPTION=Heme containing glycosylated bovine lactoperoxidase complex with carbonate, thiocyanate, calcium (green) and iodide (purple) ions [[2ips]] }}
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| <!-- | | <StructureSection load='3eri' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> |
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| | == Function == |
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| | '''Lactoperoxidase''' (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion<ref>PMID:10837362</ref>. |
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| | == Relevance == |
| '''Lactoperoxidase''' (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. The short-lived oxidized intermediates of the reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion. | | The short-lived oxidized intermediates of the LPO reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. |
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| ==3D structures of lactoperoxidase== | | ==3D structures of lactoperoxidase== |
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| | == References == |
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Revision as of 08:59, 10 April 2016
<StructureSection load='3eri' size='350' side='right' caption='Human α-defensin 1 (PDB entry 2pm4)' scene=>
Function
Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion[1].
Relevance
The short-lived oxidized intermediates of the LPO reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions.
3D structures of lactoperoxidase
Updated on 10-April-2016
{"openlevels":0}
- Lactoperoxidase binary complex
- 2pt3 - bPLO + phosphate - bovine
- 2nqx – bPLO + I
- 2r5l – gLPO + I – goat
- 3nak – gLPO + formate
- 4ig5, 4qyq – gLPO + antithyroid agent
- Lactoperoxidase ternary complex
- 2gj1 – bLPO + carbonate + nitrate
- 2ips, 3eri, 3gc1 – bLPO + SCN + I
- 2qrb – bLPO + SCN + Cl
- 3bxi – bLPO + SCN + nitrate
- 4pnx - bPLO + bromomethane + I
- 2pum – bPLO + catechol + I
- 2gj1 – bLPO + carbonate + nitrate
- 3krq – bLPO + amino-triazole + I
- 2z5z – wbPLO + F + I – water buffalo
- 2o86 – wbPLO + nitrate + I
- 3erh - wbLPO + SCN + I
- 2ojv – gPLO + CN + I
- 3n8f - gLPO + SCN + nitrate
- 3niu – gLPO + diethylene glycol + phosphate
- 3rke - gPLO + inhibitor + I
- 2ikc – sLPO + carbonate + formate – sheep
- Lactoperoxidase quaternary complex
- 3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
- 3gck - bPLO + benzylhydroxamic acid + SCN + I
- 3uba, 4gm7 - bPLO + hydroxycinnamic acid + SCN + I
- 3gcl, 2qqt - bPLO + aspirin + SCN + I
- 3i6n - bPLO + isoniazid + SCN + I
- 4ksz - bPLO + cystein + SCN + I
- 3nyh - bPLO + Br + Cl + SCN + I
- 3ogw - bPLO + indomethacin + SCN + I
- 3py4, 4gn6 - bPLO + paracetamol + SCN + I
- 3q9k - bPLO + phenyliso-SCN + SCN + I
- 3ql6 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
- 3s4f, 4njb, 4nt3 - bPLO + pyridine derivative + SCN + I
- 3r4x, 3tuw - bPLO + pyrazine derivative + SCN + I
- 3r5o - bPLO + methoxyphenol + SCN + I
- 3tgy - bPLO + ascorbate + SCN + I
- 3v6q - bPLO + CO + SCN + I
- 2gjm - wbPLO + carbonate + SCN + I
- 3faq – wbLPO + CN + SCN + I
- 3fnl - wbPLO + salicylhydroxamic acid + SCN + I
- 2e9e – gPLO + nitrate + carbonate + SCN + CN
- 2efb – gPLO + phosphate + carbonate + SCN + CN
- 3qf1 - gPLO + piperazine + SCN + I
- 4ljj - gPLO + acrylonitrile + SCN + I
- 4msf, 4oek - gPLO + phenol derivative+ SCN + I
- 2eha – gPLO + formate + carbonate + SCN
- 3r55, 4n7a - gPLO + pyrazine derivative + SCN + I
- 3sxv - gPLO + amitrole + SCN + I
- 3r5q - sPLO +tetrahydrofuran + SCN + I
- 4qjq - gPLO + octopamine + SCN + I
- 4s0y - bLPO + butyl-triazole + SCN + I
- 4y55 - wbLPO + rhodanide + SCN + I
- ↑ Gerson C, Sabater J, Scuri M, Torbati A, Coffey R, Abraham JW, Lauredo I, Forteza R, Wanner A, Salathe M, Abraham WM, Conner GE. The lactoperoxidase system functions in bacterial clearance of airways. Am J Respir Cell Mol Biol. 2000 Jun;22(6):665-71. PMID:10837362
References
