Sandbox Reserved 434: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 35: | Line 35: | ||
Vanin 1 is a key protein that is involved in the breakdown of pantetheine to panthothenic acid and cysteamine. These proteins are associated with many metabolic diseases like type 2 diabetes. Understanding the binding interaction would give insight into treating these diseases more effectively. Vanin 1 has three catalytic residues (Glu79, Lys178 and Cys211) that represents the active site of the enzyme.The active site is located in the center of the enzyme in between the two sub-units. It was discovered that Glu79 and Lys178 were responsible for orienting and activating Cys211 to catalyze the reaction. The substrate forms a covalent bond with Cys211 producing the transition state. | Vanin 1 is a key protein that is involved in the breakdown of pantetheine to panthothenic acid and cysteamine. These proteins are associated with many metabolic diseases like type 2 diabetes. Understanding the binding interaction would give insight into treating these diseases more effectively. Vanin 1 has three catalytic residues (Glu79, Lys178 and Cys211) that represents the active site of the enzyme.The active site is located in the center of the enzyme in between the two sub-units. It was discovered that Glu79 and Lys178 were responsible for orienting and activating Cys211 to catalyze the reaction. The substrate forms a covalent bond with Cys211 producing the transition state. | ||
<scene name='48/483891/Glu249_and_glu439/2'>GLU249 AND GLU439</scene> | In addition, the two residues <scene name='48/483891/Glu249_and_glu439/2'>GLU249 AND GLU439</scene> are essential for enzymatic function too. The two glutamic acid residues are both located in hydrophobic parts of the protein 4 Angstrom away. Although this is energetically unfavorable to have a polar amino acid in a nonpolar region, these two amino acids help maintain the structure between the two sub-units for proper binding interactions to occur. | ||
==Additional Features== | ==Additional Features== | ||
